Chapter 16
유전자 발현과 기능의 분석
체외 돌연변이 유발
To learn more about the function of a gene, researchers can observe what happens when the gene is inactivated or “knocked out,” by creating ...
유전자 검사
Genetic screens are tools used to identify genes and mutations responsible for phenotypes of interest. Genetic screens help identify individuals or a ...
크로스 테스트
Alleles are different forms of the same gene. Humans and other diploid organisms inherit two alleles of every gene, one from each parent.
An allele is ...
보완 테스트
A complementation test is a simple cross to identify whether the two mutations are located on the same gene or different genes. It was first performed by ...
단일 뉴클레오티드 다형성-SNP
A single nucleotide polymorphism or SNP is a single nucleotide variation at a specific genomic position in a large population. It is the most prevalent ...
박테리아 형질전환
In 1928, bacteriologist Frederick Griffith worked on a vaccine for pneumonia, which is caused by Streptococcus pneumoniae bacteria. Griffith studied two ...
형질전환 유기체
Overview
Transgenic organisms are genetically engineered to carry transgenes—genes from a different species—as part of their genome. The ...
생식 클로닝
Reproductive cloning is the process of producing a genetically identical copy—a clone—of an entire organism. While clones can be produced by ...
크리스퍼
Genome editing technologies allow scientists to modify an organism’s DNA via the addition, removal, or rearrangement of genetic material at specific ...
실험용 RNAi
RNA interference (RNAi) is a cellular mechanism that inhibits gene expression by suppressing its transcription or activating the RNA degradation process. ...
리포터 유전자
Reporter genes are a type of protein-coding gene that are often tagged to a gene of interest. Once inside a target cell, reporter genes usually ...
In-situ 하이브리드화
In situ hybridization (ISH) is a technique used to detect and localize specific DNA or RNA molecules in cells, tissue, or tissue sections using a labeled ...
염색질 면역침전(chromatin immunoprecipitation) - ChIP
Chromatin immunoprecipitation, or ChIP, is an antibody-based technique used to identify sites on DNA that bind to transcription factors of interest or ...
합성생물학
Synthetic biology is an interdisciplinary science that involves using principles from disciplines such as engineering, molecular biology, cell biology, ...
리보솜 프로파일링
Ribosome profiling or ribo-sequencing is a deep sequencing technique that produces a snapshot of active translation in a cell. It selectively sequences ...
유전자 변형 식물
Recombinant DNA technology called transgenesis is often used to add a foreign gene or remove a detrimental gene from an organism. Such genetically ...
유전자 치료
Gene therapy is a technique where a gene is inserted into a person’s cells to prevent or treat a serious disease. The added gene may be a healthy ...
에피스타시스 분석
Although Mendel chose seven unrelated traits in peas to study gene segregation, most traits involve multiple gene interactions that create a spectrum of ...
게놈 전체 연관 연구-GWAS
Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more ...
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