Name: handheld metal detector screening for metallic foreign body ingestion in children
Uploaded: 2018-09-11T15:00:00.000+00:00
Duration: 4 min 55 s
Description: Watch this Scientific Journal Video about Handheld Metal Detector Screening for Metallic Foreign Body Ingestion in Children at JoVE.com

Yazarlar Dr Lee Khai Pin, Head & Kıdemli Danışman, çocuk acil, KK kadın ve Çocuk Hastanesi, 100 Bukit Timah Road, Singapur video makale üretimi ile idari destek için teşekkür ederiz. Makale "El Metal Dedektörü için metalik yabancı beden Ingestion içinde çocuk acil"; izniyle çoğaltılamaz Ağustos 2018:85 (8): 618-624; Hazwani Binte Hamzah, gece nöbeti James, Suraj Manickam, Sashikumar Ganapathy: Hint Pediatri Dergisi telif hakkı.

Protokol kurumsal insan Araştırma Etik Komitesi kuralları izler. Merkezi Kurumsal değerlendirme komitesi etik onay çalışma için sağlanan.
1. katılımcı eleme
<ol><li>Pediatrik acil bölümü yabancı cisim yenmesi için geçmişi ile mevcut hastalarda işe.</li>
	<li>Solunum sıkıntısı ve yapımcıları hızı gibi cihazlar implante hastalar hariç.</li>
</ol>2. hasta hazırlamak
<ol><li>Hasta bir hastane elbisesi elbise.</li>
	<li>Giysi, Gözlük, küpe, kolye ve süsler HHMD tarama girişimi engellemek için sınav öncesinde gibi metal nesneler içeren tüm öğeleri kaldırın.</li>
	<li>Hasta olası metalik partiküllü uzak odanın ortasına yerleştirin.</li>
</ol>3. sınav ve bakıcılar hazırlamak
<ol><li>Mücevher ve saat gibi tüm metalik aksesuarları kaldırın.</li>
	<li>Mücevher ve saat gibi tüm metalik aksesuarları kaldırmak için caregiver isteyin.</li>
</ol>4. metal detektörü tarama
<ol><li>HHMD (Şekil 1) tarama yapmak için kullanın.</li>
	<li>Bir metal parçası üzerinde sallayarak tarafından olumlu bir görsel-işitsel sinyal alabilme tarafından HHMD çalışma durumunu doğrulayın.</li>
	<li>HHMD ayakta pozisyonda daha büyük çocuklar için tarama gerçekleştirin.</li>
	<li>HHMD dik bir pozisyonda bebekler için uygun şekilde hasta bakıcı tutun sahip olarak tarama gerçekleştirin.</li>
	<li>Hasta yukarı ve vücuttan tutuşun.</li>
	<li>Pozisyon hastanın Başkanı uzantıdaki boyun ortaya çıkarmak için.</li>
	<li>Çene düzeyinden leğen kemiği için boyun alanları anatomik kapsayacak şekilde kalça eklemi seviyesine inceden inceye gözden geçirmek.</li>
	<li>Tarama her alanda taranan sağlamak için vücut arasında bir zikzak şekilde gerçekleştirin.</li>
	<li>Hasta kalınlığı dikkate alınması gereken gibi her ikisi de anteriorly ve özafagusu inceden inceye gözden geçirmek.</li>
	<li>Dikkatli bir şekilde olumlu görsel-işitsel sinyal MFBs varlığı için tarama sırasında dikkat edin.</li>
</ol>5. ilgili grafisi gerçekleştirmek
<ol><li>Boyun, göğüs ve karın, ilgili grafisi HHMD tarama MFBs için tarafından algılanan alan göre sipariş.</li>
	<li>Yabancı cisim yenmesi yüksek olduğu için MFB HHMD tarama ve şüphe klinik Dizin sırasında algılanmadı tüm X-ray görünümleri ile (boyun, göğüs ve karın) devam edin.</li>
</ol>6. Test sonuçlarını kaydetmek
<ol><li>Kayıt özel olarak oluşturulan seyir defteri (Şekil 2) test sonuçlarında temel iş akışı (resim 1).</li>
	<li>Olumlu görsel-işitsel HHMD sinyal aşağıdaki önemli kemikli yerler - sternal çentik, xiphisternum, kasık symphysis ve ikili iliyak taç palpating tarafından gövde, temel alınan kemikli Simgesel Yapı ile ilişkili.</li>
	<li>Landmark seyir defteri'nın anatomik başvuru anahat x-ışını muayene işlemine devam etmeden önce kayıt.</li>
</ol>

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Yazarlar ifşa gerek yok.

Metalik yabancı beden ingestion çocuklarda yaygın bir sorundur ve bu hastaların çoğunda, konservatif7,16yönetilen. Tek veya yinelenen ilerlemenin radyo duyarlı Pediatrik popülasyon istenmeyen radyasyon riski için alınan metalik yabancı cisim yerelleştirmek çalışırken açığa çıkarabilir. Çeşitli çalışmalarda MFB yenmesi çocuklar, hassasiyetle fazla % 96 ve özgüllük % 801,7<sup...

Yabancı cisim yeme bebek ve çocuklarda tatma ve onları1,2yutma nesneleri keşfetmeye doğal meraklı doğası nedeniyle Pediatrik acil servis sunan çocuklar arasında yaygın bir sorundur. Önceki çalışmalarda metalik nesneleri tüm yabancı cisim ingestions onların kohort hastalar3,%485'i oluşturdu bildirdi. Bu iletişim kuralı, doğruluk ve hafızanın metalik yabancı organları çocuklarda algılamak için bir el metal detektörü kullanarak fizibilite değerlendirmek için hedeftir. Önerdiğimiz Protokolü metalik yabancı cisim yenmesi yüksek şüphe ile çocukların değerlendirme işleminin başında eleme el metal detektörü tanıtarak, metalik yabancı cisim yerelleştirmek için sipariş edilen ilerlemenin sayısı olabilir Bu radyo duyarlı nüfus içinde azalır.
El metal dedektörü (HHMD) yönetimi hafızanın metalik yabancı cisimlerin hızlandırmak yardımcı olabilir bir ucuz, kolay erişilebilir adjunct olduğunu. Metal dedektörü bir alıcı ve onun çevresinde3metal bir nesnenin varlığı nedeniyle, elektromanyetik alan değişikliği algılar bir verici olan bir çok düşük frekanslı cihazdır. Metalik bir nesne alan içinde ise, elektromanyetik alan bozulur ve sensör görsel-işitsel alarm cihazı4kapalı koyacaktır. Metal dedektörü muayene iyice 2 dakika5' ten daha az sayıda gerçekleştirilir. Bu nedenle, HHMD tarama metalik yabancı cisim yeme topografik yerelleştirme için yüksek şüphe ile çocukların değerlendirme işleminin başında tanıttı olabilir.
En yaygın yuttu metalik yabancı organları1,4,6,7vardır. Keskin kenarlar ve genel toksik olmayan doğa olmaması nedeniyle sikke ingestions çoğunluğu konservatif yönetilir. Diğer türleri yaygın olarak yutulur malzemelerin mıknatıslar, düğme piller, küçük oyuncaklar, fıstık, takı, düğmeler, kemikler, tohum ve patlamış mısır8,9içerir. Yabancı cisimlerin impaksiyon en çok üç siteleri, yani üst özofagus sfinkter, aort ve alt özofagus sfinkter10düzeyinde orta yemek borusu, yemek borusu oluşur. Yemek borusu içinde bulunan metalik yabancı organları (MFBs)-ebilmek var olmak asemptomatik hastaların11,%12 40've onun uzun süreli impaksiyon özofagus perforasyon, mediastinitis gibi çeşitli komplikasyonlara yol açabilir, tracheoesophageal fistül, trakeal stenoz ve sendromlarda özofagus fistüller1,13,14,15. Yabancı cisim impaksiyon diğer yerlerini mide, onikiparmak bağırsağı ve Ileocecal caecal junction10içerir.
İlerlemenin boyun, göğüs ve karın tanılamak için performans yabancı cisim yeme acil bölümler5yaygın bir uygulamadır şüpheli. Tüm alınan yabancı cisimlerin arasında sadece % 10 radyo-opak10türleridir. Radyolojik testleri zaman alıcı ve çocuklarda radyasyona maruz kalma riski var. Hafızanın metal nesnelerin hassas topografik yerelleştirme tedavi Kılavuzu çok önemlidir. Erken değerlendirme sürecinde eleme HHMD getirilmesi yabancı ilerlemenin arazi hafızanın metalik yabancı cisim yerelleştirme tarafından sipariş azaltmak yardımcı olabilir.
Bu çalışmada HHMD MFBs sistematik bir topografik moda yerelleştirmek için doğruluğunu değerlendirildi ve etkinliği ve HHMD fizibilite yerel pediatrik popülasyonda belirledi. Biz de ne kadar iyi bu radyasyon tarama gereci ücretsiz hastalar ve veliler tarafından kabul edildi inceledi. Mayıs ve Temmuz 2016 arasında Pediatrik acil bölümü yabancı cisim yenmesi için bir geçmiş ile sunulan tüm ardışık hasta çalışmaya dahil. Aydınlatılmış onam ebeveyn veya vasi elde edildi. Hasta olduğu iddia edilen yabancı cisim yenmesi ile sistematik olarak HHMD kullanarak tarandı. Altın standart tedavi için kimlik ve yerelleştirme hafızanın metalik yabancı cisimlerin servikal alan, göğüs ve karın düz ilerlemenin gerçekleştiriyor. Çalışma yürütülmesi kolaylaştırmak için standart bir iş akışı (resim 1) oluşturuldu. Özellikle iş akışında alarak oluşturulan bir seyir defteri daha sonra bir e-tabloya (Şekil 2) transkripsiyonu ilk veri toplamak için kullanıldı. Sonuç bölümündeki veriler yüzdeleri tarafından takip servis taleplerinin sayısı olarak tasvir edilir.

<table><tbody><tr><td>Hand held metal detector</td><td>Garrett Super Scanner V</td><td>NA</td><td>NA</td></tr></tbody></table>

handheld metal detector screening for metallic foreign body ingestion in children

Çocuklar arasında en yaygın hafızanın metalik yabancı organları vardır. Bu iletişim kuralı, doğruluk ve hafızanın metalik yabancı organları çocuklarda algılamak için bir el metal detektörü kullanarak fizibilite değerlendirmek için hedeftir. Önerdiğimiz el metal detektörü tarama metalik yabancı cisim yenmesi yüksek şüphe ile çocukların değerlendirme işleminin başında tanıtarak, metalik yabancı cisim yerelleştirmek için sipariş edilen ilerlemenin sayısı bu azaltılabilir Radyo duyarlı nüfus. Metalik implant veya yabancı cisim yeme öyküsü ve solunum yetmezliği olan hastalar dışlanması için katılımcılar ile taranması çalışma protokolü gerektirir. Hasta hastane elbisesi ve gözlük, küpe, kolye gibi metal içeren öğeleri değiştirir ve süs eşyaları kaldırılır. Hasta metalik partiküllü uzak odanın ortasına konumlandırılmış. El metal detektörü çalışma durumunu ilk olumlu bir görsel-işitsel sinyal alabilme tarafından onaylanır. Sonra tarama dik bir pozisyonda baş boyun, leğen kemiği bir zikzak şekilde anatomik alanlarına boyun anteriorly ve özafagusu kapsayacak şekilde ve kalça eklemi, seviyesine çene düzeyinden maruz uzantısındaki ile yapılır. Olumlu bir görsel-işitsel sinyal dikkatle metalik yabancı cisim varlığı için tarama sırasında dikkate alındı. İlgili ilerlemenin metal detektörü tarama tespit alan göre sıralanır. El metal detektörü çalışma hafızanın metalik yabancı organları arasında bütün paralar tam olarak tespit edebilmek. El metal detektörü sikke metalik yabancı organları sürekli olarak algılanamadı. Bu iletişim kuralı kimliği el metal dedektör doğruluğunu ve yerelleştirme ve bozuk para gibi metalik yabancı organları gösterir.

Araştırmacılar bu gözlem çalışması için 36 hasta işe. Bu hastaların Pediatrik acil bölümü yabancı cisim yenmesi için bir geçmiş ile gerçekleştirmişti. Bunlar arasında metalik yabancı cisim ingestions (Şekil 3) 28 hasta vardı. Kalan 8 hasta balık kemikleri, satay sopa ve plastik düğme gibi metalik olmayan yabancı organları yutulur. Paralar %30,5 hastaların oluşan yabancı cisim (Tablo 1), yutulur en yaygın tür...

Watch this Scientific Journal Video about Handheld Metal Detector Screening for Metallic Foreign Body Ingestion in Children at JoVE.com

Handheld Metal Detector Screening for Metallic Foreign Body Ingestion in Children

Burada, el metal detektörü, hafızanın metalik yabancı organları yabancı cisim yeme öyküsü olan çocuk acil tıp bölümü mevcut çocuklarda varlığı için ekran için kullanılacak iletişim kuralı mevcut.

Metalik yabancı cisim yeme çocuklar için el Metal detektörü tarama

Coins are the most common ingested metallic foreign bodies among children. The goal of this protocol is to assess the accuracy and feasibility of using a ...

handheld-metal-detector-screening-for-metallic-foreign-body-ingestion

Universidad de Cartagena UDEC

Research

JoVE Journal

Medicine

10.6K Görüntüleme.  KK women's and Children's Hospital. Burada, el metal detektörü, hafızanın metalik yabancı organları yabancı cisim yeme öyküsü olan çocuk acil tıp bölümü mevcut çocuklarda varlığı için ekran için kullanılacak iletişim kuralı mevcut.

Video: Handheld Metal Detector Screening for Metallic Foreign Body Ingestion in Children

Bacterial Detection &amp; Identification Using Electrochemical Sensors

Electrochemical sensors are widely used for rapid and accurate measurement of blood glucose and can be adapted for detection of a wide variety of analytes. Electrochemical sensors operate by transducing a biological recognition event into a useful electrical signal. Signal transduction occurs by coupling the activity of a redox enzyme to an amperometric electrode. Sensor specificity is either an inherent characteristic of the enzyme, glucose oxidase in the case of a glucose sensor, or a product of linkage between the enzyme and an antibody or probe.
Here, we describe an electrochemical sensor assay method to directly detect and identify bacteria. In every case, the probes described here are DNA oligonucleotides. This method is based on sandwich hybridization of capture and detector probes with target ribosomal RNA (rRNA). The capture probe is anchored to the sensor surface, while the detector probe is linked to horseradish peroxidase (HRP). When a substrate such as 3,3',5,5'-tetramethylbenzidine (TMB) is added to an electrode with capture-target-detector complexes bound to its surface, the substrate is oxidized by HRP and reduced by the working electrode. This redox cycle results in shuttling of electrons by the substrate from the electrode to HRP, producing current flow in the electrode.

Bacterial Detection & Identification Using Electrochemical Sensors

We describe an electrochemical sensor assay method for rapid bacterial detection and identification. The assay involves a sensor array functionalized with DNA oligonucleotide capture probes for ribosomal RNA (rRNA) species-specific sequences. Sandwich hybridization of target rRNA with the capture probe and a horseradish peroxidase-linked DNA oligonucleotide detector probe produces a measurable amperometric current.

Elektrokimyasal Sensörler kullanarak Bakteriyel Algılama ve Tanıma

Electrochemical  sensors are widely used for rapid and accurate measurement of blood glucose and  can be adapted for detection of a wide variety of ...

Biyomühendislik

Protocol for the Evaluation of MRI Artifacts Caused by Metal Implants to Assess the Suitability of Implants and the Vulnerability of Pulse Sequences

As the number of magnetic resonance imaging (MRI) scanners and patients with medical implants is constantly growing, radiologists increasingly encounter metallic implant-related artifacts in MRI, resulting in reduced image quality. Therefore, the MRI suitability of implants in terms of artifact volume, as well as the development of pulse sequences to reduce image artifacts, are becoming more and more important. Here, we present a comprehensive protocol which allows for a standardized evaluation of the artifact volume of implants on MRI. Furthermore, this protocol can be used to analyze the vulnerability of different pulse sequences to artifacts. The proposed protocol can be applied to T1- and T2-weighted images with or without fat-suppression and all passive implants. Furthermore, the procedure enables the separate and three-dimensional identification of signal loss and pile-up artifacts. As previous investigations differed greatly in evaluation methods, the comparability of their results was limited. Thus, standardized measurements of MRI artifact volumes are necessary to provide better comparability. This may improve the development of the MRI suitability of implants and better pulse sequences to finally improve patient care.

We describe a standardized method to evaluate magnetic resonance imaging artifacts caused by implants to estimate the suitability of the implants for magnetic resonance imaging and/or the vulnerability of different pulse sequences to metallic artifacts simultaneously.

İmplantlar uygunluğu ve güvenlik açığı darbe sıralarının değerlendirmek için Metal tarafından neden MRI eserler değerlendirilmesi için iletişim kuralı implantlar

As the number of magnetic resonance imaging (MRI) scanners and patients with medical implants is constantly growing, radiologists increasingly encounter ...

Mühendislik

Making MR Imaging Child's Play - Pediatric Neuroimaging Protocol, Guidelines and Procedure

Within the last decade there has been an increase in the use of structural and functional magnetic resonance imaging (fMRI) to investigate the neural basis of human perception, cognition and behavior 1, 2. Moreover, this non-invasive imaging method has grown into a tool for clinicians and researchers to explore typical and atypical brain development. Although advances in neuroimaging tools and techniques are apparent, (f)MRI in young pediatric populations remains relatively infrequent 2. Practical as well as technical challenges when imaging children present clinicians and research teams with a unique set of problems 3, 2. To name just a few, the child participants are challenged by a need for motivation, alertness and cooperation. Anxiety may be an additional factor to be addressed. Researchers or clinicians need to consider time constraints, movement restriction, scanner background noise and unfamiliarity with the MR scanner environment2,4-10. A progressive use of functional and structural neuroimaging in younger age groups, however, could further add to our understanding of brain development. As an example, several research groups are currently working towards early detection of developmental disorders, potentially even before children present associated behavioral characteristics e.g.11. Various strategies and techniques have been reported as a means to ensure comfort and cooperation of young children during neuroimaging sessions. Play therapy 12, behavioral approaches 13, 14,15, 16-18 and simulation 19, the use of mock scanner areas 20,21, basic relaxation 22 and a combination of these techniques 23 have all been shown to improve the participant's compliance and thus MRI data quality. Even more importantly, these strategies have proven to increase the comfort of families and children involved 12. One of the main advances of such techniques for the clinical practice is the possibility of avoiding sedation or general anesthesia (GA) as a way to manage children's compliance during MR imaging sessions 19,20. In the current video report, we present a pediatric neuroimaging protocol with guidelines and procedures that have proven to be successful to date in young children.

Despite an increase in the use of structural and functional magnetic resonance imaging (fMRI) in humans, the study of young pediatric populations remains a challenge. We present a hands-on, step-by-step video protocol including guidelines for clinicians and researchers intending to perform (f)MRI in young children.

Pediatrik Nörogörüntüleme Protokol Kuralları ve Usulü - MR Görüntüleme Çocuk Oyunu

Within the last decade there has been an increase in the use of structural and functional magnetic resonance imaging (fMRI) to investigate the neural ...

Biyoloji

Ferromagnetic Bare Metal Stent for Endothelial Cell Capture and Retention

Rapid endothelialization of cardiovascular stents is needed to reduce stent thrombosis and to avoid anti-platelet therapy which can reduce bleeding risk. The feasibility of using magnetic forces to capture and retain endothelial outgrowth cells (EOC) labeled with super paramagnetic iron oxide nanoparticles (SPION) has been shown previously. But this technique requires the development of a mechanically functional stent from a magnetic and biocompatible material followed by in-vitro and in-vivo testing to prove rapid endothelialization. We developed a weakly ferromagnetic stent from 2205 duplex stainless steel using computer aided design (CAD) and its design was further refined using finite element analysis (FEA). The final design of the stent exhibited a principal strain below the fracture limit of the material during mechanical crimping and expansion. One hundred stents were manufactured and a subset of them was used for mechanical testing, retained magnetic field measurements, in-vitro cell capture studies, and in-vivo implantation studies. Ten stents were tested for deployment to verify if they sustained crimping and expansion cycle without failure. Another 10 stents were magnetized using a strong neodymium magnet and their retained magnetic field was measured. The stents showed that the retained magnetism was sufficient to capture SPION-labeled EOC in our in-vitro studies. SPION-labeled EOC capture and retention was verified in large animal models by implanting 1 magnetized stent and 1 non-magnetized control stent in each of 4 pigs. The stented arteries were explanted after 7 days and analyzed histologically. The weakly magnetic stents developed in this study were capable of attracting and retaining SPION-labeled endothelial cells which can promote rapid healing.

Our goals were to design, manufacture and test ferromagnetic stents for endothelial cell capture. Ten stents were tested for fracture and 10 more stents were tested for retained magnetism. Finally, 10 stents were tested in-vitro and 8 more stents were implanted in 4 pigs to show cell capture and retention.

Endotel Hücre yakalama ve Saklanmasına İlişkin ferromanyetik Bare Metal Stent

Rapid endothelialization of cardiovascular stents is needed to reduce stent thrombosis and to avoid anti-platelet therapy which can reduce bleeding risk. ...

Preparation and Application of a New Bacterial Biosensor for the Presumptive Detection of Gunshot Residue

MicRoboCop is a biosensor that has been designed for a unique application in forensic chemistry. MicRoboCop is a system made up of three devices that, when used together, can indicate the presence of gunshot residue (GSR) by producing a fluorescence signal in the presence of three key analytes (antimony, lead, and organic components of GSR). The protocol describes the synthesis of the biosensors using Escherichia coli (E. coli), and the analytical chemistry methods used to evaluate the selectivity and sensitivity of the sensors. The functioning of the system is demonstrated by using GSR collected from the inside of a spent cartridge casing. Once prepared, the biosensors can be stored until needed and can be used as a test for these key analytes. A positive response from all three analytes provides a presumptive positive test for GSR, while each individual device has applications for detecting the analytes in other samples (e.g., a detector for lead contamination in drinking water). The main limitation of the system is the time required for a positive signal; future work may involve studying different organisms to optimize the response time.

A protocol is presented using synthetic biology techniques to synthesize a set of bacterial biosensors for the analysis of gunshot residue, and to test the functioning of the devices for their intended use using fluorescence spectroscopy.

Silah kalıntılarının varsayımsal tespiti için yeni bir bakteriyel biyosensörün hazırlanması ve uygulanması

MicRoboCop is a biosensor that has been designed for a unique application in forensic chemistry. MicRoboCop is a system made up of three devices that, ...

Kimya

Hellgrammite as a Non-Conventional Biomonitor for Surface Water and Environmental Health Assessment

The larvae of dobsonflies from the genus Corydalus, commonly known as Hellgrammites, are characterized by their notable size, extensive range of occurrence, and extended period of immaturity, which can last up to one year. Hellgrammites are clearly known to exhibit sensitivity to pollution and habitat structure impacts. Given these unique features, using Corydalus texanus larvae is highly suitable as reliable biomonitoring agents to assess the ecological integrity of aquatic ecosystems. This protocol aims to provide the necessary tools for C. texanus assessment and demonstrate their efficacy through a case study. Research findings have practical implications, indicating that C. texanus larvae exhibit early-warning responses to mining pollution, bioaccumulating high amounts of heavy metals such as Zn, Fe, and Al. The presence or absence of C. texanus populations may serve as a helpful indicator for identifying potential issues related to ecosystem health. The unconventional approach has shown early warnings of pollution in mining-impacted sites, highlighting the need for timely action to protect the environment. Given their unique traits, the use of C. texanus larvae is highly suggested as a reliable non-conventional bioindicator.

This protocol describes the use of biomarkers for the early detection of deleterious impacts in aquatic ecosystems. The biomarkers are closely related to sentinel traits, and their changes aid in detecting early-warning damages.

Yüzey Suyu ve Çevre Sağlığı Değerlendirmesi için Konvansiyonel Olmayan Bir Biyomonitör Olarak Hellgrammite

The larvae of dobsonflies from the genus Corydalus, commonly known as Hellgrammites, are characterized by their notable size, extensive range of ...

Çevre

Quantification of Metal Leaching in Immobilized Metal Affinity Chromatography

Contamination of enzymes with metals leached from immobilized metal affinity chromatography (IMAC) columns poses a major concern for enzymologists, as many of the common di-and trivalent cations used in IMAC resins have an inhibitory effect on enzymes. However, the extent of metal leaching and the impact of various eluting and reducing reagents are poorly understood in large part due to the absence of simple and practical transition metal quantification protocols that use equipment typically available in biochemistry labs. To address this problem, we have developed a protocol to quickly quantify the amount of metal contamination in samples prepared using IMAC as a purification step. The method uses hydroxynaphthol blue (HNB) as a colorimetric indicator for metal cation content in a sample solution and UV-Vis spectroscopy as a means to quantify the amount of metal present, into the nanomolar range, based on the change in the HNB spectrum at 647 nm. While metal content in a solution has historically been determined using atomic absorption spectroscopy or inductively coupled plasma techniques, these methods require specialized equipment and training outside the scope of a typical biochemistry laboratory. The method proposed here provides a simple and fast way for biochemists to determine the metal content of samples using existing equipment and knowledge without sacrificing accuracy.

We present an assay for easy quantification of metals introduced to samples prepared using immobilized metal affinity chromatography. The method uses hydroxynaphthol blue as the colorimetric metal indicator and a UV-Vis spectrophotometer as the detector.

Immobilize Metal Affinity Kromatografisinde Metal Yıkamanın Ölçülmesi

Contamination of enzymes with metals leached from immobilized metal affinity chromatography (IMAC) columns poses a major concern for enzymologists, as ...

Magnetic Levitation Coupled with Portable Imaging and Analysis for Disease Diagnostics

Currently, many clinical diagnostic procedures are complex, costly, inefficient, and inaccessible to a large population in the world. The requirements for specialized equipment and trained personnel require that many diagnostic tests be performed at remote, centralized clinical laboratories. Magnetic levitation is a simple yet powerful technique and can be applied to levitate cells, which are suspended in a paramagnetic solution and placed in a magnetic field, at a position determined by equilibrium between a magnetic force and a buoyancy force. Here, we present a versatile platform technology designed for point-of-care diagnostics which uses magnetic levitation coupled to microscopic imaging and automated analysis to determine the density distribution of a patient's cells as a useful diagnostic indicator. We present two platforms operating on this principle: (i) a smartphone-compatible version of the technology, where the built-in smartphone camera is used to image cells in the magnetic field and a smartphone application processes the images and to measures the density distribution of the cells and (ii) a self-contained version where a camera board is used to capture images and an embedded processing unit with attached thin-film-transistor (TFT) screen measures and displays the results. Demonstrated applications include: (i) measuring the altered distribution of a cell population with a disease phenotype compared to a healthy phenotype, which is applied to sickle cell disease diagnosis, and (ii) separation of different cell types based on their characteristic densities, which is applied to separate white blood cells from red blood cells for white blood cell cytometry. These applications, as well as future extensions of the essential density-based measurements enabled by this portable, user-friendly platform technology, will significantly enhance disease diagnostic capabilities at the point of care.

We present a magnetic levitation technique coupled with automated imaging and analysis in both a smartphone-compatible device and a device with embedded imaging and processing. This is applied to measure the density distribution of cells with two demonstrated biomedical applications: sickle cell disease diagnosis and separating white and red blood cells.

Hastalık Teşhis için Taşınabilir Görüntüleme ve Analiz ile birleştiğinde Manyetik Levitasyonunun

Currently, many clinical diagnostic procedures are complex, costly, inefficient, and inaccessible to a large population in the world. The requirements for ...

Magnetic Stirrer Method for the Detection of Trichinella Larvae in Muscle Samples

Trichinellosis is a debilitating disease in humans and is caused by the consumption of raw or undercooked meat of animals infected with the nematode larvae of the genus Trichinella. The most important sources of human infections worldwide are game meat and pork or pork products. In many countries, the prevention of human trichinellosis is based on the identification of infected animals by means of the artificial digestion of muscle samples from susceptible animal carcasses.
There are several methods based on the digestion of meat but the magnetic stirrer method is considered the gold standard. This method allows the detection of Trichinella larvae by microscopy after the enzymatic digestion of muscle samples and subsequent filtration and sedimentation steps. Although this method does not require special and expensive equipment, internal controls cannot be used. Therefore, stringent quality management should be applied throughout the test. The aim of the present work is to provide detailed handling instructions and critical control points of the method to analysts, based on the experience of the European Union Reference Laboratory for Parasites and the National Reference Laboratory of Germany for Trichinella.

Magnetic Stirrer Method for the Detection of Trichinella Larvae in Muscle Samples

The prevention of human trichinellosis in many countries worldwide is based on the laboratory examination of muscle samples from susceptible animals by methods of digestion, of which the magnetic stirrer method is considered the gold standard.

Tespiti için Manyetik Karıştırıcı Yöntemi<em&gt; Trichinella</emKas Samples&gt; Larva

Trichinellosis is a debilitating disease in humans and is caused by the consumption of raw or undercooked meat of animals infected with the nematode ...

İmmünoloji ve Enfeksiyon

Foodborne Pathogen Screening Using Magneto-fluorescent Nanosensor: Rapid Detection of E. Coli O157:H7

Enterohemorrhagic Escherichia coli O157:H7 has been linked to both waterborne and foodborne illnesses, and remains a threat despite the food- and water-screening methods used currently. While conventional bacterial detection methods, such as polymerase chain reaction (PCR) and enzyme-linked immunosorbent assays (ELISA) can specifically detect pathogenic contaminants, they require extensive sample preparation and lengthy waiting periods. In addition, these practices demand sophisticated laboratory instruments and settings, and must be executed by trained professionals. Herein, a protocol is proposed for a simpler diagnostic technique that features the unique combination of magnetic and fluorescent parameters in a nanoparticle-based platform. The proposed multiparametric magneto-fluorescent nanosensors (MFnS) can detect E. coli O157:H7 contamination with as little as 1 colony-forming unit present in solution within less than 1 h. Furthermore, the ability of MFnS to remain highly functional in complex media such as milk and lake water has been verified. Additional specificity assays were also used to demonstrate the ability of MFnS to only detect the specific target bacteria, even in the presence of similar bacterial species. The pairing of magnetic and fluorescent modalities allows for the detection and quantification of pathogen contamination in a wide range of concentrations, exhibiting its high performance in both early- and late-stage contamination detection. The effectiveness, affordability, and portability of the MFnS make them an ideal candidate for point-of-care screening for bacterial contaminants in a wide range of settings, from aquatic reservoirs to commercially packaged foods.

Foodborne Pathogen Screening Using Magneto-fluorescent Nanosensor: Rapid Detection of E. Coli O157:H7

The overall goal of this protocol is to synthesize functional nanosensors for the portable, cost-effective, and rapid detection of specifically targeted pathogenic bacteria through a combination of magnetic relaxation and fluorescence emission modalities.

Metalik yabancı cisim yeme çocuklar için el Metal detektörü tarama

Özet

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