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Core - Pharmacology

    Chapter 21

    Drugs for Peptic Ulcer Disease

    21.1 : Pathophysiology of Peptic Ulcer Disease: Injurious Factors01:22

    21.1 : Pathophysiology of Peptic Ulcer Disease: Injurious Factors

    Peptic ulcers are sores in the mucosa of the stomach or duodenum. The mucosal epithelium houses acid-secreting parietal and gastrin-secreting G cells. The ...

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    21.2 : Pathophysiology of Peptic Ulcer Disease: Mucosal Defense Factors01:24

    21.2 : Pathophysiology of Peptic Ulcer Disease: Mucosal Defense Factors

    Peptic ulcer disease, or PUD, involves discontinuous gastrointestinal tract lining due to gastric acid or pepsin secretion. The mucus-bicarbonate barrier ...

    356 views
    21.3 : Acid Suppressive Drugs for Peptic Ulcer Disease: Proton Pump Inhibitors01:13

    21.3 : Acid Suppressive Drugs for Peptic Ulcer Disease: Proton Pump Inhibitors

    Two of the main contributors to peptic ulcer formation are H. pylori infections or NSAID use, both facilitating gastric acid production. Gastric acid is ...

    358 views
    21.4 : Acid Suppressive Drugs for Peptic Ulcer Disease: Histamine H2-Receptor Antagonists01:28

    21.4 : Acid Suppressive Drugs for Peptic Ulcer Disease: Histamine H2-Receptor Antagonists

    Histamine H2 receptors are G protein-coupled receptors located on the basolateral membrane of parietal cells. Histamine released from ECL cells binds to ...

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    21.5 : Acid Suppressive Drugs for Peptic Ulcer Disease: Antacids01:31

    21.5 : Acid Suppressive Drugs for Peptic Ulcer Disease: Antacids

    In the gastric lumen, increased acid secretion can form or exacerbate ulcers in the mucosal layer. Carbonate antacids, like sodium bicarbonate and calcium ...

    330 views
    21.6 : Drugs for Peptic Ulcer Disease: Sucralfate as Mucosal Protective Agents01:24

    21.6 : Drugs for Peptic Ulcer Disease: Sucralfate as Mucosal Protective Agents

    Recall that increased acid secretion in the gastric lumen disrupts mucosal defense mechanisms and weakens the mucus-bicarbonate barrier. This enables ...

    390 views
    21.7 : Drugs for Peptic Ulcer Disease: Prostaglandin Analogs as Mucosal Protective Agents01:20

    21.7 : Drugs for Peptic Ulcer Disease: Prostaglandin Analogs as Mucosal Protective Agents

    The gastric mucosa majorly produces prostaglandin E2 and I2 to protect cells from mucosal injury. These bind to EP3 receptors, which couple with ...

    351 views
    21.8 : Treating Helicobacter pylori in Peptic Ulcers: Antimicrobial Therapy01:16

    21.8 : Treating Helicobacter pylori in Peptic Ulcers: Antimicrobial Therapy

    Helicobacter pylori or H. pylori, a gram-negative bacillus, thrives in the stomach's acidic environment, impairing somatostatin production. This ...

    328 views
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