Nós reconhecemos o apoio financeiro de Ciências Naturais e Engenharia do Conselho de Investigação do Canadá (NSERC, # 436117-2013), a Sociedade de Pesquisa do Câncer (CRS, # 20172), mieloma Canadá e Grande Challenges Canada.

Note-se que todos os passos descritos abaixo, foram desenvolvidos e realizados num ambiente não-salas limpas. Os passos de ligação de solventes pode certamente ser realizada de uma sala limpa, se disponível, mas isso não é necessário. 1. Preparação de camadas do dispositivo termoplástico microfluídicos <ol><li> Concepção e fabrico de camadas Dispositivo de microfluidos da termoplástico de escolha, utilizando um método de fabricação adequado (por exemplo, microfresagem 15, gravação em relevo 16-18, moldagem por injecção). </li><li> Inspecione visualmente camadas de dispositivos para garantir que as bordas são &quot;limpas&quot; (isto é, sem rebarbas ou saliências de material restante do processo de fabricação). Para obter melhores resultados, verifique todas as arestas em recursos micro usinadas, além das bordas externas do dispositivo sob um microscópio óptico. </li><li> Se o material restante é encontrado durante a inspeção visual, use uma lâmina de barbear ou bisturi para remover cuidadosamente qualquer material que impede que as camadas do dispositivo a partir deitado uma contra a outra de modo que as interfaces das camadas entram em contacto conformada. </li><li> dispositivo de limpar as superfícies com sabão de laboratório e água e seque com ar comprimido. Submergir camadas de dispositivos em 2-propanol durante 2 minutos e seque com ar comprimido. </li></ol> 2. colagem por solvente <ol><li> Prepare prensa aquecida (para PMMA) ou placa de aquecimento (para COP). <ol><li> Por PMMA (acrílico fundido, temperatura de transição de vidro de ~ 100-110 ° C) 18 de pré-aquecimento prima a 70 ° C, e permitir que a temperatura estabilize. </li><li> Para COP (temperatura de transição vítrea de 102 ° C, a partir do fabricante), pré-aquecer placa de aquecimento a 25 ° C, e permitir que a temperatura estabilize. </li></ol></li><li> Prepare solvente para processo de colagem. <ol><li> Para PMMA, medir 0,5 ml de etanol por polegada quadrada de área de colagem. </li><li> Para COP, prepare uma mistura 65:35 de 2-propanol e ciclo-hexano, sagacidadeha volume total de 0,5 ml da mistura por polegada quadrada da área de adesão. NOTA: Para COP, utilize pipetas de vidro e recipientes, como ciclo-hexano vai dissolver o material de laboratório polipropileno comum. Executar todas mistura e colagem numa hotte, como ciclo-hexano é tóxico. </li></ol></li><li> Pipetar 0,1 ml de solvente por polegada quadrada de área de adesão entre as camadas de plástico limpas e trazer as camadas em conjunto. Verifique visualmente se bolhas de ar na interface de ligação, que são comuns e devem ser removidos, tanto quanto possível. NOTA: É vantajoso trabalhar rapidamente uma vez que o solvente tenha sido distribuído, como solventes voláteis começará a evaporar-se (e, por conseguinte, misturas de solventes mudará na composição). <ol><li> Se as bolhas estão presentes, deslize as duas camadas de plástico ao longo da interface de ligação de modo que eles quase se desfazer (mas permanecer em contato) e, em seguida, deslize-los juntos novamente. </li></ol></li><li> Alinhar as camadas do dispositivo com pinos de alinhamento,um gabarito personalizado, ou simplesmente com a mão (ver secção Discussão para mais detalhes). <ol><li> Se usar pinos de alinhamento, alinhe os furos para os pinos, e insira os pinos na pilha do dispositivo. </li><li> Se estiver usando um gabarito personalizado, insira a pilha do dispositivo para o gabarito e aperte em torno do dispositivo. </li><li> Se o alinhamento com a mão, usar os dedos para alinhar as bordas exteriores do dispositivo. </li></ol></li><li> Coloque o dispositivo com solvente para a imprensa pré-aquecido (para PMMA) ou sobre a placa de aquecimento pré-aquecido (para COP). <ol><li> Por PMMA, aplicam-se 2300 kPa de pressão durante 2 minutos. </li><li> Para COP, aplicar 350 kPa de pressão. Aumentar a temperatura de 25 ° C a 70 ° C a uma velocidade de 5 ° C / min. Depois de atingir 70 ° C (depois de 9 minutos), a ligação para um adicional de 15 min. </li></ol></li><li> Use uma pinça para remover com segurança o dispositivo quente para inspeção. A ligação é agora completa. </li><li> Remover restos de líquido no dispositivo (em microcanais ou outras features). <ol><li> Para PMMA, remover qualquer líquido restante com ar comprimido. Para COP, colocar o dispositivo ligado na placa de aquecimento e leve ao forno a 45 ° C durante 24 horas para remover qualquer ciclohexano restante. </li></ol></li></ol>

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Os autores declaram que não têm interesses financeiros concorrentes.

A viabilidade das estratégias de ligação potenciais depende de equipamentos disponíveis. Enquanto placas são relativamente comuns e pesos livres podem ser comprados a baixo custo, as estratégias de alta pressão vai requerer o uso de uma prensa aquecida. Por exemplo, a ligação óptima receita PMMA requer alta pressão para ligar-se com etanol (ver Tabela 1), e a pressão necessária não é atingível para os tamanhos dos dispositivos típicos usando pesos livres. Assim, mesmo que apenas uma pla...

Microfluídica tem emergido nos últimos vinte anos como uma tecnologia adequada para estudar química e física em microescala 1, e com a promessa de crescimento para contribuir significativamente para a biologia da pesquisa 2-4. A maioria dos dispositivos de microfluidos foram historicamente feita a partir de poli (dimetilsiloxano) (PDMS), um elastómero de silicone que é fácil de usar, de baixo custo, e oferece a replicação característica de alta qualidade 5. No entanto, o PDMS tem deficiências bem documentado e é incompatível com a fabricação de alto volume processa 6,7, e, como tal, tem havido uma tendência crescente para a fabricação de dispositivos de microfluidos de materiais termoplásticos, devido ao seu potencial para a fabricação de massa e, assim, a comercialização. Uma das principais barreiras para a adoção mais ampla de microfabricação de plástico vem alcançando fácil ligação qualidade, alta de dispositivos de plástico. As estratégias atuais empregam tHermal, adesiva, e as técnicas de ligação de solventes, mas muitos sofrem de desafios significativos. A ligação térmica aumenta a autofluorescência 8 e muitas vezes deforma geometrias de microcanais 9-11, enquanto que as técnicas adesivas requerem stencils, o alinhamento cuidadoso e, finalmente deixar a espessura do adesivo exposto ao microcanal 10. Colagem solvente é atraente devido à sua simplicidade, tunability, e baixo custo de 10,12 - 14. Em particular, a sua tunability permite a optimização para uma variedade de plásticos, que pode produzir consistente qualidade de ligação, elevada que minimiza a deformação da microcaracterísticas 14. Durante a ligação por solvente, a exposição a solventes aumenta a mobilidade das cadeias de polímero perto da superfície do plástico, o que permite a inter-difusão de cadeias através do interface de ligação. Isto faz com que por meio de emaranhamento de bloqueio mecânico das cadeias de difusora, e resulta em APvínculo hysical 10. A ligação térmica funciona de uma maneira semelhante, mas baseia-se na temperatura elevada por si só para aumentar a mobilidade da cadeia. Assim, os métodos térmicos requerem temperaturas próximas ou acima da transição de vidro do polímero, ao passo que o uso de solventes pode reduzir significativamente a temperatura necessária para a ligação e, assim, reduzir a deformação indesejada. Nós fornecemos um protocolo específico para a colagem de ambos os dispositivos COP PMMA e. No entanto, este protocolo e método descreve uma abordagem simples, genérico para a ligação de solvente de dispositivos microfluídicos termoplásticos que pode ser adaptado para outros materiais plásticos, solventes e equipamento disponível. Nós descrevemos vários métodos para avaliar a qualidade de ligações (por exemplo, a cobertura de ligação, resistência de união, durabilidade bond, e deformação das geometrias microfeature), e fornecer abordagens de solução de problemas para resolver estes desafios comuns.

<table border="1" fo:keep-together.within-page="1" fo:keep-with-next.within-page="always">
	<tbody>
		<tr>
			<td>COP</td>
			<td>Zeonor</td>
			<td>604Z1020R080</td>
			<td>20 kg COP Pellets - 1020R. Multiple suppliers can be used, but may affect bonding characteristics.</td>
		</tr>
		<tr>
			<td>PMMA</td>
			<td>McMaster Carr</td>
			<td>8560K173</td>
			<td>1.5 mm sheet thickness for our typical applications. Multiple suppliers can be used, but may affect bonding characteristics.</td>
		</tr>
		<tr>
			<td>Cyclohexane</td>
			<td>Sigma-Aldrich</td>
			<td>227048</td>
			<td>Cyclohexane, anhydrous, 99.5%. Multiple suppliers can be used. Toxic, requires fumehood.</td>
		</tr>
		<tr>
			<td>Ethanol</td>
			<td>Sigma-Aldrich</td>
			<td>24102</td>
			<td>Ethanol, absolute, &#8805;99.8% (GC). Multiple suppliers can be used.</td>
		</tr>
		<tr>
			<td>Acetone</td>
			<td>Sigma-Aldrich</td>
			<td>179124</td>
			<td>Acetone, ACS reagent, &#8805;99.5%. Multiple suppliers can be used.</td>
		</tr>
		<tr>
			<td>2-Propanol</td>
			<td>Sigma-Aldrich</td>
			<td>278475</td>
			<td>2-Propanol, anhydrous, 99.5%. Multiple suppliers can be used.</td>
		</tr>
		<tr>
			<td>Hot plate(s)</td>
			<td>Torrey Pines Scientific</td>
			<td>HP60</td>
			<td>Fully programmable digital hotplate. Multiple suppliers can be used.</td>
		</tr>
		<tr>
			<td>Free weights</td>
			<td>Cap Barbell</td>
			<td>RPG#2</td>
			<td>Standard cast iron plate. Multiple suppliers and different weights can be used.</td>
		</tr>
		<tr>
			<td>Heated press</td>
			<td>Carver</td>
			<td>Auto CH</td>
			<td>Auto series heated hydraulic press. Multiple suppliers can be used. A press that fits in a fumehood would allow the most flexibility (this model does not).</td>
		</tr>
		<tr>
			<td>CNC Milling Machine</td>
			<td>Tormach</td>
			<td>PCNC 770</td>
			<td>3 Axis CNC mill. Multiple suppliers can be used.</td>
		</tr>
		<tr>
			<td>Endmills</td>
			<td>Various</td>
			<td>Various</td>
			<td>Required sizes depend on designs. Multiple suppliers can be used.</td>
		</tr>
	</tbody>
</table>

solvent bonding for fabrication of pmma and cop microfluidic devices

microcanais termoplásticos oferecem muitas vantagens sobre aqueles feitos a partir de elastómeros de silicone, mas os procedimentos de ligação deve ser desenvolvida para cada um termoplástico de interesse. ligação por solvente é um método simples e versátil, que pode ser utilizado para fabricar os dispositivos a partir de uma variedade de plásticos. Um solvente apropriado é adicionado entre as duas camadas do dispositivo a ser ligado, e o calor e a pressão são aplicadas ao dispositivo, para facilitar a ligação. Através da utilização de uma combinação apropriada de solvente, de plástico, de calor e pressão, o dispositivo pode ser selado com uma ligação de alta qualidade, caracterizado por ter uma alta cobertura de ligação, força de ligação, claridade óptica, durabilidade ao longo do tempo, e baixa deformação ou danos para microfeature geometria. Descreve-se o procedimento para os dispositivos de ligação fabricados a partir de materiais termoplásticos conhecidos, poli (metil-metacrilato) (PMMA), e polímeros de ciclo-olefina (COP), bem como uma variedade de métodos para caracterizar a qualidade das ligações resultantes, e estratégias para troubleshoot títulos de baixa qualidade. Estes métodos podem ser utilizados para desenvolver novos protocolos de ligação por solvente para outros sistemas de plástico de solvente.

Um diagrama esquemático do processo de colagem por solvente geral é mostrada na Figura 1. A maneira mais fácil de avaliar a qualidade do vínculo é inspecionar visualmente a cobertura de obrigações, uma vez que a cobertura pobre ligação é facilmente visível como regiões de plástico unbonded, e é indicativo de vínculo fraco. Essas regiões são tipicamente bordas livres perto (por exemplo, periferia do dispositivo, ou próximo portas abertas ou micr...

Watch this Scientific Journal Video about Solvent Bonding for Fabrication of PMMA and COP Microfluidic Devices at JoVE.com

Solvent Bonding for Fabrication of PMMA and COP Microfluidic Devices

colagem solvente é um método simples e versátil para a fabricação de dispositivos microfluídicos termoplásticos com títulos de alta qualidade. Nós descrevemos um protocolo para alcançar laços fortes, opticamente transparentes em PMMA e dispositivos microfluídicos COP que preservam detalhes microfeature, por uma combinação judiciosa de pressão, temperatura, num solvente apropriado, e da geometria do dispositivo.

Bonding solvente para Fabricação de PMMA e COP microfluídicos

Thermoplastic microfluidic devices offer many advantages over those made from silicone elastomers, but bonding procedures must be developed for each ...

solvent-bonding-for-fabrication-of-pmma-and-cop-microfluidic-devices

Universidad de Cartagena UDEC

Research

JoVE Journal

Engineering

16.1K visualizações.  University of Toronto.  colagem solvente é um método simples e versátil para a fabricação de dispositivos microfluídicos termoplásticos com títulos de alta qualidade. Nós descrevemos um protocolo para alcançar laços fortes, opticamente transparentes em PMMA e dispositivos microfluídicos COP que preservam detalhes microfeature, por uma combinação judiciosa de pressão, temperatura, num solvente apropriado, e da geometria do dispositivo. 

Vídeo: Solvent Bonding for Fabrication of PMMA and COP Microfluidic Devices

Fabrication of Uniform Nanoscale Cavities via Silicon Direct Wafer Bonding

Measurements of the heat capacity and superfluid fraction of confined 4He have been performed near the lambda transition using lithographically patterned and bonded silicon wafers. Unlike confinements in porous materials often used for these types of experiments3, bonded wafers provide predesigned uniform spaces for confinement. The geometry of each cell is well known, which removes a large source of ambiguity in the interpretation of data.
Exceptionally flat, 5 cm diameter, 375 &#181;m thick Si wafers with about 1 &#181;m variation over the entire wafer can be obtained commercially (from Semiconductor Processing Company, for example). Thermal oxide is grown on the wafers to define the confinement dimension in the z-direction. A pattern is then etched in the oxide using lithographic techniques so as to create a desired enclosure upon bonding. A hole is drilled in one of the wafers (the top) to allow for the introduction of the liquid to be measured. The wafers are cleaned2 in RCA solutions and then put in a microclean chamber where they are rinsed with deionized water4. The wafers are bonded at RT and then annealed at ~1,100 &#176;C. This forms a strong and permanent bond. This process can be used to make uniform enclosures for measuring thermal and hydrodynamic properties of confined liquids from the nanometer to the micrometer scale.

A method for permanently bonding two silicon wafers so as to realize a uniform enclosure is described. This includes wafer preparation, cleaning, RT bonding, and annealing processes. The resulting bonded wafers (cells) have uniformity of enclosure ~1%1,2. The resulting geometry allows for measurements of confined liquids and gasses.

Fabricação de cavidades de nanoescala uniformes via Silicon Direct Wafer Bonding

Measurements of the heat capacity and superfluid fraction of confined 4He have been performed near the lambda transition using lithographically patterned ...

Engenharia

Fabrication and Testing of Microfluidic Optomechanical Oscillators

Cavity optomechanics experiments that parametrically couple the phonon modes and photon modes have been investigated in various optical systems including microresonators. However, because of the increased acoustic radiative losses during direct liquid immersion of optomechanical devices, almost all published optomechanical experiments have been performed in solid phase. This paper discusses a recently introduced hollow microfluidic optomechanical resonator. Detailed methodology is provided to fabricate these ultra-high-Q microfluidic resonators, perform optomechanical testing, and measure radiation pressure-driven breathing mode and SBS-driven whispering gallery mode parametric vibrations. By confining liquids inside the capillary resonator, high mechanical- and optical- quality factors are simultaneously maintained.

Parametric optomechanical excitations have recently been experimentally demonstrated in microfluidic optomechanical resonators by means of optical radiation pressure and stimulated Brillouin scattering. This paper describes the fabrication of these microfluidic resonators along with methodologies for generating and verifying optomechanical oscillations.

Fabricação e Teste de microfluídicos optomechanical osciladores

Cavity optomechanics experiments that parametrically couple the phonon modes and photon modes have been investigated in various optical systems including ...

Fabrication of Gate-tunable Graphene Devices for Scanning Tunneling Microscopy Studies with Coulomb Impurities

Owing to its relativistic low-energy charge carriers, the interaction between graphene and various impurities leads to a wealth of new physics and degrees of freedom to control electronic devices. In particular, the behavior of graphene&#8217;s charge carriers in response to potentials from charged Coulomb impurities is predicted to differ significantly from that of most materials. Scanning tunneling microscopy (STM) and scanning tunneling spectroscopy (STS) can provide detailed information on both the spatial and energy dependence of graphene&#39;s electronic structure in the presence of a charged impurity.&#160;The design of a hybrid impurity-graphene device, fabricated using controlled deposition of impurities onto a back-gated graphene surface, has enabled several novel methods for controllably tuning graphene&#8217;s electronic properties.1-8 Electrostatic gating enables control of the charge carrier density in graphene and the ability to reversibly tune the charge2 and/or molecular5 states of an impurity. This paper outlines the process of fabricating a gate-tunable graphene device decorated with individual Coulomb impurities for combined STM/STS studies.2-5 These studies provide valuable insights into the underlying physics, as well as signposts for designing hybrid graphene devices.

This paper details the fabrication process of a gate-tunable graphene device, decorated with Coulomb impurities for scanning tunneling microscopy studies. Mapping the spatially dependent electronic structure of graphene in the presence of charged impurities unveils the unique behavior of its relativistic charge carriers in response to a local Coulomb potential.

Fabricação de porta-ajustáveis ​​dispositivos de grafeno para tunelamento estudos de microscopia com Coulomb Impurezas

Owing to its relativistic low-energy charge carriers, the interaction between graphene and various impurities leads to a wealth of new physics and degrees ...

Thermal Measurement Techniques in Analytical Microfluidic Devices

Thermal measurement techniques have been used for many applications such as thermal characterization of materials and chemical reaction detection. Micromachining techniques allow reduction of the thermal mass of fabricated structures and introduce the possibility to perform high sensitivity thermal measurements in the micro-scale and nano-scale devices. Combining thermal measurement techniques with microfluidic devices allows performing different analytical measurements with low sample consumption and reduced measurement time by integrating the miniaturized system on a single chip. The procedures of thermal measurement techniques for particle detection, material characterization, and chemical detection are introduced in this paper.

Here, we present three protocols for thermal measurements in microfluidic devices.

Técnicas de Medição térmicos em analíticos microfluídicos

Thermal measurement techniques have been used for many applications such as thermal characterization of materials and chemical reaction detection. ...

Fabrication and Operation of Acoustofluidic Devices Supporting Bulk Acoustic Standing Waves for Sheathless Focusing of Particles

Acoustophoresis refers to the displacement of suspended objects in response to directional forces from sound energy. Given that the suspended objects must be smaller than the incident wavelength of sound and the width of the fluidic channels are typically tens to hundreds of micrometers across, acoustofluidic devices typically use ultrasonic waves generated from a piezoelectric transducer pulsating at high frequencies (in the megahertz range). At characteristic frequencies that depend on the geometry of the device, it is possible to induce the formation of standing waves that can focus particles along desired fluidic streamlines within a bulk flow. Here, we describe a method for the fabrication of acoustophoretic devices from common materials and clean room equipment. We show representative results for the focusing of particles with positive or negative acoustic contrast factors, which move towards the pressure nodes or antinodes of the standing waves, respectively. These devices offer enormous practical utility for precisely positioning large numbers of microscopic entities (e.g., cells) in stationary or flowing fluids for applications ranging from cytometry to assembly.

Acoustofluidic devices use ultrasonic waves within microfluidic channels to manipulate, concentrate and isolate suspended micro and nanoscopic entities. This protocol describes the fabrication and operation of such a device supporting bulk acoustic standing waves to focus particles in a central streamline without the aid of sheath fluids.

Fabricação e operação de Acoustofluidic dispositivos que suportam a granel ondas acústicas pe para Sheathless Focando de Partículas

Acoustophoresis refers to the displacement of suspended objects in response to directional forces from sound energy. Given that the suspended objects must ...

Fabrication of Fully Solution Processed Inorganic Nanocrystal Photovoltaic Devices

We demonstrate a method for the preparation of fully solution processed inorganic solar cells from a spin and spray coating deposition of nanocrystal inks. For the photoactive absorber layer, colloidal CdTe and CdSe nanocrystals (3-5 nm) are synthesized using an inert hot injection technique and cleaned with precipitations to remove excess starting reagents. Similarly, gold nanocrystals (3-5 nm) are synthesized under ambient conditions and dissolved in organic solvents. In addition, precursor solutions for transparent conductive indium tin oxide (ITO) films are prepared from solutions of indium and tin salts paired with a reactive oxidizer. Layer-by-layer, these solutions are deposited onto a glass substrate following annealing (200-400 &#176;C) to build the nanocrystal solar cell (glass/ITO/CdSe/CdTe/Au). Pre-annealing ligand exchange is required for CdSe and CdTe nanocrystals where films are dipped in NH4Cl:methanol to replace long-chain native ligands with small inorganic Cl- anions. NH4Cl(s) was found to act as a catalyst for the sintering reaction (as a non-toxic alternative to the conventional CdCl2(s) treatment) leading to grain growth (136&#177;39 nm) during heating. The thickness and roughness of the prepared films are characterized with SEM and optical profilometry. FTIR is used to determine the degree of ligand exchange prior to sintering, and XRD is used to verify the crystallinity and phase of each material. UV/Vis spectra show high visible light transmission through the ITO layer and a red shift in the absorbance of the cadmium chalcogenide nanocrystals after thermal annealing. Current-voltage curves of completed devices are measured under simulated one sun illumination. Small differences in deposition techniques and reagents employed during ligand exchange have been shown to have a profound influence on the device properties. Here, we examine the effects of chemical (sintering and ligand exchange agents) and physical treatments (solution concentration, spray-pressure, annealing time and annealing temperature) on photovoltaic device performance.

This protocol describes the synthesis and solution deposition of inorganic nanocrystals layer by layer to produce thin film electronics on non-conductive surfaces. Solvent-stabilized inks can produce complete photovoltaic devices on glass substrates via spin and spray coating following post-deposition ligand exchange and sintering.

Fabricação de Solução totalmente processado inorgânicos nanocristais fotovoltaicos Devices

We demonstrate a method for the preparation of fully solution processed inorganic solar cells from a spin and spray coating deposition of nanocrystal ...

Scanning Light Scattering Profiler (SLPS) Based Methodology to Quantitatively Evaluate Forward and Backward Light Scattering from Intraocular Lenses

The scanning light scattering profiler (SLSP) methodology has been developed for the full-angle quantitative evaluation of forward and backward light scattering from intraocular lenses (IOLs) using goniophotometer principles. This protocol describes the SLSP platform and how it employs a 360&#176; rotational photodetector sensor that is scanned around an IOL sample while recording the intensity and location of scattered light as it passes through the IOL medium. The SLSP platform can be used to predict, non-clinically, the propensity for current and novel IOL designs and materials to induce light scatter. Non-clinical evaluation of light scattering properties of IOLs can significantly reduce the number of patient complaints related to unwanted glare, glistening, optical defects, poor image quality, and other phenomena associated with the unintended light scattering. Future studies should be conducted to correlate SLSP data with clinical results to help identify which measured light scatter is most problematic for patients that have undergone cataract surgery subsequent to IOL implantation.

Scanning Light Scattering Profiler SLPS Based Methodology to Quantitatively Evaluate Forward and Backward Light Scattering from Intraocular Lenses

This protocol describes the scanning light scattering profiler (SLSP) that enables the full-angle quantitative evaluation of forward and backward scattering of light from intraocular lenses (IOLs) using goniophotometer principles.

Metodologia baseada em Scanning Light Scattering Profiler (SLPS) para avaliar quantitativamente a dispersão de luz para frente e para trás a partir de lentes intraoculares

The scanning light scattering profiler (SLSP) methodology has been developed for the full-angle quantitative evaluation of forward and backward light ...

Flow-assisted Dielectrophoresis: A Low Cost Method for the Fabrication of High Performance Solution-processable Nanowire Devices

Flow-assisted dielectrophoresis (DEP) is an efficient self-assembly method for the controllable and reproducible positioning, alignment, and selection of nanowires. DEP is used for nanowire analysis, characterization, and for solution-based fabrication of semiconducting devices. The method works by applying an alternating electric field between metallic electrodes. The nanowire formulation is then dropped onto the electrodes which are on an inclined surface to create a flow of the formulation using gravity. The nanowires then align along the gradient of the electric field and in the direction of the liquid flow. The frequency of the field can be adjusted to select nanowires with superior conductivity and lower trap density. 
In this work, flow-assisted DEP is used to create nanowire field effect transistors. Flow-assisted DEP has several advantages: it allows selection of nanowire electrical properties; control of nanowire length; placement of nanowires in specific areas; control of orientation of nanowires; and control of nanowire density in the device. 
The technique can be expanded to many other applications such as gas sensors and microwave switches. The technique is efficient, quick, reproducible, and it uses a minimal amount of dilute solution making it ideal for the testing of novel nanomaterials. Wafer scale assembly of nanowire devices can also be achieved using this technique, allowing large numbers of samples for testing and large-area electronic applications.

In this paper, flow assisted dielectrophoresis is demonstrated for the self-assembly of nanowire devices. The fabrication of a silicon nanowire field effect transistor is shown as an example.

Dieletroforese assistida por fluxo: Um método de baixo custo para a fabricação de dispositivos de solução-processable nanofio de alto desempenho

Flow-assisted dielectrophoresis (DEP) is an efficient self-assembly method for the controllable and reproducible positioning, alignment, and selection of ...

Atmospheric Pressure Fabrication of Large-Sized Single-Layer Rectangular SnSe Flakes

Tin selenide (SnSe) belongs to the family of layered metal chalcogenide materials with a buckled structure like phosphorene, and has shown potential for applications in two-dimensional nanoelectronics devices. Although many methods to synthesize SnSe nanocrystals have been developed, a simple way to fabricate large-sized single-layer SnSe flakes remains a great challenge. Herein, we show the experimental method to directly grow large-sized single-layer rectangular SnSe flakes on commonly used SiO2/Si insulating substrates using a straightforward two-step fabrication method in an atmospheric pressure quartz tube furnace system. The single-layer rectangular SnSe flakes with an average thickness of ~6.8 &#197; and lateral dimensions of about 30 &#181;m &#215; 50 &#181;m were fabricated by a combination of vapor transport deposition technique and nitrogen etching route. We characterized the morphology, microstructure, and electrical properties of the rectangular SnSe flakes and obtained excellent crystallinity and good electronic properties. This article about the two-step fabrication method can help researchers grow other similar two-dimensional, large-sized, single-layer materials using an atmospheric pressure system.

A protocol is presented demonstrating a two-step fabrication technique to grow large-sized single-layer rectangular shaped SnSe flakes on low-cost SiO2/Si dielectrics wafers in an atmospheric pressure quartz tube furnace system.

Fabricação de pressão atmosférica de grande porte camada única retangular SnSe flocos

Tin selenide (SnSe) belongs to the family of layered metal chalcogenide materials with a buckled structure like phosphorene, and has shown potential for ...

Fabrication of Refractive-index-matched Devices for Biomedical Microfluidics

The use of microfluidic devices has emerged as a defining tool for biomedical applications. When combined with modern microscopy techniques, these devices can be implemented as part of a robust platform capable of making simultaneous complementary measurements. The primary challenge created by the combination of these two techniques is the mismatch in refractive index between the materials traditionally used to make microfluidic devices and the aqueous solutions typically used in biomedicine. This mismatch can create optical artifacts near the channel or device edges. One solution is to reduce the refractive index of the material used to fabricate the device by using a fluorinated polymer such as MY133-V2000 whose refractive index is similar to that of water (n = 1.33). Here, the construction of a microfluidic device made out of MY133-V2000 using soft lithography techniques is demonstrated, using O2 plasma in conjunction with an acrylic holder to increase the adhesion between the MY133-V2000 fabricated device and the polydimethylsiloxane (PDMS) substrate. The device is then tested by incubating it filled with cell culture media for 24 h to demonstrate the ability of the device to maintain cell culture conditions during the course of a typical imaging experiment. Finally, quantitative phase microscopy (QPM) is used to measure the distribution of mass within the live adherent cells in the microchannel. This way, the increased precision, enabled by fabricating the device from a low index of refraction polymer such as MY133-V2000 in lieu of traditional soft lithography materials such as PDMS, is demonstrated. Overall, this approach for fabricating microfluidic devices can be readily integrated into existing soft lithography workflows in order to reduce optical artifacts and increase measurement precision.

This protocol describes the fabrication of microfluidic devices from MY133-V2000 to eliminate artifacts that often arise in microchannels due to the mismatching refractive indices between microchannel structures and an aqueous solution. This protocol uses an acrylic holder to compress the encapsulated device, improving adhesion both chemically and mechanically.

Fabricação de dispositivos de refração-índice-combinada para microfluídica biomédica

The use of microfluidic devices has emerged as a defining tool for biomedical applications. When combined with modern microscopy techniques, these devices ...

Bonding solvente para Fabricação de PMMA e COP microfluídicos

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Fabricação e Teste de microfluídicos optomechanical osciladores

Fabricação de porta-ajustáveis ​​dispositivos de grafeno para tunelamento estudos de microscopia com Coulomb Impurezas

Técnicas de Medição térmicos em analíticos microfluídicos

Fabricação e operação de Acoustofluidic dispositivos que suportam a granel ondas acústicas pe para Sheathless Focando de Partículas

Fabricação de Solução totalmente processado inorgânicos nanocristais fotovoltaicos Devices

Metodologia baseada em Scanning Light Scattering Profiler (SLPS) para avaliar quantitativamente a dispersão de luz para frente e para trás a partir de lentes intraoculares

Dieletroforese assistida por fluxo: Um método de baixo custo para a fabricação de dispositivos de solução-processable nanofio de alto desempenho

Fabricação de pressão atmosférica de grande porte camada única retangular SnSe flocos

Fabricação de dispositivos de refração-índice-combinada para microfluídica biomédica

Fabricação de porta-ajustáveis dispositivos de grafeno para tunelamento estudos de microscopia com Coulomb Impurezas