Chapter 15
Mass Spectrometry Fragmentation Methods
Espectrometria de massa: fragmentação de alcanos de cadeia longa
The molecular ions of linear alkanes prefer to fragment at the carbon-carbon bond away from the end of the chain since the cleavage of an inner bond ...
Espectrometria de massa: fragmentação ramificada de alcano
This lesson delves into the mass spectrometry of branched alkane fragmentation. Branched alkanes possess secondary or tertiary carbon atoms, which ...
Espectrometria de massa: fragmentação de cicloalcanos
In mass spectrometry, cycloalkanes exhibit distinct fragmentation patterns due to the inherent stability of their molecular ions compared to linear or ...
Espectrometria de massa: fragmentação de alcenos
Alkenes lose one electron from the unsaturated π bond upon ionization and form stable molecular ions. Further fragmentation of alkenes occurs through ...
Espectrometria de massa: fragmentação de cicloalceno
The molecular ions of cycloalkenes undergo fragmentation via a retro-Diels–Alder reaction.
The reaction proceeds via the cleavage of two ...
Espectrometria de massa: fragmentação de alcino
The fragmentation of alkynes preferentially occurs at the carbon–carbon bond between the α and β carbon of the alkyne bond to generate a ...
Espectrometria de massa: fragmentação do álcool
Alcohols (R-OH) ionize to lose one non-bonded electron from the oxygen atom, forming molecular ions. Due to their tendency to fragment rapidly, the ...
Espectrometria de massas: fragmentação de compostos aromáticos
Upon ionization, aromatic compounds generate a molecular ion that is observed as a prominent peak in their mass spectra. For example, the molecular ion ...
Espectrometria de massa: fragmentação de aminas
Amines can be identified using mass spectroscopy based on their characteristic fragmentation patterns. The molecular ions of amines undergo fragmentation ...
Mass Spectrometry: Alkyl Halide Fragmentation
Chlorine isotopes exist as 35Cl and 37Cl in a 3:1 ratio, while bromine isotopes exist as 79Br and 81Br in a 1:1 ratio. The mass spectrum of alkyl halides ...
Mass Spectrometry: Alkyl Halide Fragmentation
Chlorine isotopes exist as 35Cl and 37Cl in a 3:1 ratio, while bromine isotopes exist as 79Br and 81Br in a 1:1 ratio. The mass spectrum of alkyl halides ...
Espectrometria de massa: fragmentação de aldeído e cetona
In mass spectrometry, the fragmentation of aliphatic aldehydes and ketones generally occurs through three key mechanisms: α-cleavage, inductive ...
Espectrometria de massa: fragmentação de ácido carboxílico, éster e amida
The fragmentation patterns observed for compounds such as carboxylic acids, esters, and amides in the mass spectra include ⍺-cleavage and McLafferty ...
Espectrometria de Massa de Ionização Química (CI)
The molecular ion peak of a molecule in the mass spectrum provides vital information for molecular identification. However, conventional electron impact ...
Espectrometria de massa por ionização por eletrospray (ESI)
Higher molecular weight biomolecules are nonvolatile compounds that may decompose before ionizing or vaporizing during mass analysis with conventional ...
Ionização por dessorção a laser assistida por matriz (MALDI)
Matrix-assisted laser desorption ionization (MALDI) is a powerful analytical technique used in mass spectrometry. It enables the identification and ...
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