Stephany Y. Tzeng

Drug delivery strategies for therapeutic angiogenesis and antiangiogenesis.

Non-viral gene delivery nanoparticles based on poly(β-amino esters) for treatment of glioblastoma.

Synthetic poly(ester amine) and poly(amido amine) nanoparticles for efficient DNA and siRNA delivery to human endothelial cells.

Cystamine-terminated poly(beta-amino ester)s for siRNA delivery to human mesenchymal stem cells and enhancement of osteogenic differentiation.

Subtle Changes to Polymer Structure and Degradation Mechanism Enable Highly Effective Nanoparticles for siRNA and DNA Delivery to Human Brain Cancer.

Student award winner in the Ph.D. category for the 2013 society for biomaterials annual meeting and exposition, april 10-13, 2013, Boston, Massachusetts : biomaterial-mediated cancer-specific DNA delivery to liver cell cultures using synthetic poly(beta-amino ester)s.

The effect and role of carbon atoms in poly(β-amino ester)s for DNA binding and gene delivery.

A bioreducible linear poly(β-amino ester) for siRNA delivery.

(3-aminopropyl)-4-methylpiperazine end-capped poly(1,4-butanediol diacrylate-co-4-amino-1-butanol)-based multilayer films for gene delivery.

Bioengineered nanoparticles for siRNA delivery.

Bioreducible cationic polymer-based nanoparticles for efficient and environmentally triggered cytoplasmic siRNA delivery to primary human brain cancer cells.

Biodegradable polymeric nanoparticles show high efficacy and specificity at DNA delivery to human glioblastoma in vitro and in vivo.

Degradable polymer-coated gold nanoparticles for co-delivery of DNA and siRNA.

Polymeric nanoparticles for nonviral gene therapy extend brain tumor survival in vivo.

Nanoparticle-mediated transcriptional modification enhances neuronal differentiation of human neural stem cells following transplantation in rat brain.

Non-virally engineered human adipose mesenchymal stem cells produce BMP4, target brain tumors, and extend survival.

Synthesis and application of poly(ethylene glycol)-co-poly(β-amino ester) copolymers for small cell lung cancer gene therapy.

Enhancing oligodendrocyte differentiation by transient transcription activation via DNA nanoparticle-mediated transfection.

Polymeric nanoparticle-based delivery of TRAIL DNA for cancer-specific killing.

Stabilized single-injection inactivated polio vaccine elicits a strong neutralizing immune response.

The role of assembly parameters on polyplex poly(beta-amino ester) nanoparticle transfections.

Cancer-selective nanoparticles for combinatorial siRNA delivery to primary human GBM in vitro and in vivo.

Polymeric Nucleic Acid Delivery for Immunoengineering.

Cancer-Targeting Nanoparticles for Combinatorial Nucleic Acid Delivery.

Anisotropic poly(lactic-co-glycolic acid) microparticles enable sustained release of a peptide for long-term inhibition of ocular neovascularization.

Engineered nanoparticles for systemic siRNA delivery to malignant brain tumours.

In situ genetic engineering of tumors for long-lasting and systemic immunotherapy.

Biomimetic tolerogenic artificial antigen presenting cells for regulatory T cell induction.

Gene delivery for immunoengineering.

Non-viral gene delivery of HIF-1α promotes angiogenesis in human adipose-derived stem cells.

Poly(beta-amino ester)s as gene delivery vehicles: challenges and opportunities.

Suprachoroidal gene transfer with nonviral nanoparticles.

Structure-Guided Molecular Engineering of a Vascular Endothelial Growth Factor Antagonist to Treat Retinal Diseases.

Efficiency of Cytosolic Delivery with Poly(β-amino ester) Nanoparticles is Dependent on the Effective p of the Polymer.

Poly(ethylene glycol)-Poly(beta-amino ester)-Based Nanoparticles for Suicide Gene Therapy Enhance Brain Penetration and Extend Survival in a Preclinical Human Glioblastoma Orthotopic Xenograft Model.

Biodegradable Cationic Polymer Blends for Fabrication of Enhanced Artificial Antigen Presenting Cells to Treat Melanoma.

HIF-1α and HIF-2α redundantly promote retinal neovascularization in patients with ischemic retinal disease.

Photocrosslinked Bioreducible Polymeric Nanoparticles for Enhanced Systemic siRNA Delivery as Cancer Therapy.

Nanoparticle designs for delivery of nucleic acid therapeutics as brain cancer therapies.

High-throughput and high-content bioassay enables tuning of polyester nanoparticles for cellular uptake, endosomal escape, and systemic in vivo delivery of mRNA.

PAI-1 is a vascular cell-specific HIF-2-dependent angiogenic factor that promotes retinal neovascularization in diabetic patients.

ANGPTL4 influences the therapeutic response of patients with neovascular age-related macular degeneration by promoting choroidal neovascularization.

Polymeric nanoparticles for dual-targeted theranostic gene delivery to hepatocellular carcinoma.

Enhanced stability and clinical absorption of a form of encapsulated vitamin A for food fortification.

Verteporfin-loaded microparticles for radiosensitization of preclinical lung and breast metastatic spine cancer.

Shape matters: Biodegradable anisotropic nanoparticle artificial antigen presenting cells for cancer immunotherapy.

Anti-angiogenic collagen IV-derived peptide target engagement with αβ and αβ in ocular neovascularization models.

Improvement of Islet Engrafts via Treg Induction Using Immunomodulating Polymeric Tolerogenic Microparticles.

Bioengineered particles expand myelin-specific regulatory T cells and reverse autoreactivity in a mouse model of multiple sclerosis.

Polymeric nanoparticle gel for intracellular mRNA delivery and immunological reprogramming of tumors.

Biodegradable lipophilic polymeric mRNA nanoparticles for ligand-free targeting of splenic dendritic cells for cancer vaccination.

Biodegradable Polyester Nanoparticle Vaccines Deliver Self-Amplifying mRNA in Mice at Low Doses.

Biomaterial-Mediated Genetic Reprogramming of Merkel Cell Carcinoma and Melanoma Leads to Targeted Cancer Cell Killing and .

An engineered immunocytokine with collagen affinity improves the tumor bioavailability, tolerability, and therapeutic efficacy of IL-2.

Screening for lipid nanoparticles that modulate the immune activity of helper T cells towards enhanced antitumour activity.

Suprachoroidal gene transfer with nonviral nanoparticles in large animal eyes.

Phase 1, Dose Escalation, Nonrandomized, Open-Label, Clinical Trial Evaluating the Safety and Preliminary Efficacy of Allogenic Adipose-Derived Mesenchymal Stem Cells for Recurrent Glioblastoma: A Clinical Trial Protocol.

Supramolecular assembly of polycation/mRNA nanoparticles and in vivo monocyte programming.

Ligand-free biodegradable poly(beta-amino ester) nanoparticles for targeted systemic delivery of mRNA to the lungs.

Alginate-based artificial antigen presenting cells expand functional CD8 T cells with memory characteristics for adoptive cell therapy.

Highly Multiplexed Immunofluorescence PhenoCycler Panel for Murine Formalin-Fixed Paraffin-Embedded Tissues Yields Insight Into Tumor Microenvironment Immunoengineering.

Therapeutic potential and impact of nanoengineered patient-derived mesenchymal stem cells in a murine resection and recurrence model of human glioblastoma.

Production of site-specific antibody conjugates using metabolic glycoengineering and novel Fc glycovariants.

miR-217-5p NanomiRs Inhibit Glioblastoma Growth and Enhance Effects of Ionizing Radiation via EZH2 Inhibition and Epigenetic Reprogramming.

Multipronged SMAD pathway targeting by lipophilic poly(β-amino ester) miR-590-3p nanomiRs inhibits mesenchymal glioblastoma growth and prolongs survival.