Department of Oncology,
Department of Pathology
Hailin Zhu is a graduate student at Nanfang Hospital of Southern Medical University. As a graduate student in Cardiology Laboratory, he focused on the treatment of myocardial infarction and cardiac hypertrophy. There he learned the construction of myocardial infarction and cardiac hypertrophy models, which can simulate clinical disease.
In his work, he used the surgical method to create a right heart failure model, which provides new ideas for the treatment of disease. His research interests also involve the role of exosomes in cardiovascular diseases including myocardial regeneration and apoptosis.
The use of Yes-associated protein expression in the diagnosis of persistent neonatal cholestatic liver disease.
Human pathology May, 2014 | Pubmed ID: 24746211
Pharmacological activation of myosin II paralogs to correct cell mechanics defects.
Proceedings of the National Academy of Sciences of the United States of America Feb, 2015 | Pubmed ID: 25605895
A polymeric nanoparticle formulation of curcumin in combination with sorafenib synergistically inhibits tumor growth and metastasis in an orthotopic model of human hepatocellular carcinoma.
Biochemical and biophysical research communications Dec, 2015 | Pubmed ID: 26482853
Program Death 1 Immune Checkpoint and Tumor Microenvironment: Implications for Patients With Intrahepatic Cholangiocarcinoma.
Annals of surgical oncology Aug, 2016 | Pubmed ID: 27012989
Yes-associated protein impacts adherens junction assembly through regulating actin cytoskeleton organization.
American journal of physiology. Gastrointestinal and liver physiology Sep, 2016 | Pubmed ID: 27229120
Histopathological and immunophenotypic features of ipilimumab-associated colitis compared to ulcerative colitis.
Journal of internal medicine Jun, 2018 | Pubmed ID: 29464806
Transient c-Src Suppression During Endodermal Commitment of Human Induced Pluripotent Stem Cells Results in Abnormal Profibrotic Cholangiocyte-Like Cells.
Stem cells (Dayton, Ohio) Mar, 2019 | Pubmed ID: 30471152
Quantitative Characterization of CD8+ T Cell Clustering and Spatial Heterogeneity in Solid Tumors.
Frontiers in oncology , 2018 | Pubmed ID: 30666298
Persistent mutant oncogene specific T cells in two patients benefitting from anti-PD-1.
Journal for immunotherapy of cancer Feb, 2019 | Pubmed ID: 30744692
Correction to: persistent mutant oncogene specific T cells in two patients benefitting from anti-PD-1.
Journal for immunotherapy of cancer Mar, 2019 | Pubmed ID: 30841906
Multiple Immune-Suppressive Mechanisms in Fibrolamellar Carcinoma.
Cancer immunology research May, 2019 | Pubmed ID: 30902819
Programmed Cell Death Ligand-1 (PD-L1) and CD8 Expression Profiling Identify an Immunologic Subtype of Pancreatic Ductal Adenocarcinomas with Favorable Survival.
Cancer immunology research Jun, 2019 | Pubmed ID: 31043417
Axon Guidance Molecules Promote Perineural Invasion and Metastasis of Orthotopic Pancreatic Tumors in Mice.
Gastroenterology Sep, 2019 | Pubmed ID: 31163177
Targeting Mechanoresponsive Proteins in Pancreatic Cancer: 4-Hydroxyacetophenone Blocks Dissemination and Invasion by Activating MYH14.
Cancer research Sep, 2019 | Pubmed ID: 31358530
Abundant Expression of Lysyl Oxidase-like 2 Protein in Intrahepatic Bile Ducts of Infants With Biliary Atresia.
Journal of pediatric gastroenterology and nutrition Sep, 2019 | Pubmed ID: 31436671
Immunopathologic Stratification of Colorectal Cancer for Checkpoint Blockade Immunotherapy.
Cancer immunology research Oct, 2019 | Pubmed ID: 31439614
Detection of Novel Fusion Transcript VTI1A-CFAP46 in Hepatocellular Carcinoma.
Gastrointestinal tumors Aug, 2019 | Pubmed ID: 31602373
A phase 2 study of GVAX colon vaccine with cyclophosphamide and pembrolizumab in patients with mismatch repair proficient advanced colorectal cancer.
Cancer medicine Feb, 2020 | Pubmed ID: 31876399
Intraductal pancreatic cancer is less responsive than cancer in the stroma to neoadjuvant chemotherapy.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc Oct, 2020 | Pubmed ID: 32457408
Integrated immunological analysis of a successful conversion of locally advanced hepatocellular carcinoma to resectability with neoadjuvant therapy.
Journal for immunotherapy of cancer Nov, 2020 | Pubmed ID: 33219090
Vaccine-Induced Intratumoral Lymphoid Aggregates Correlate with Survival Following Treatment with a Neoadjuvant and Adjuvant Vaccine in Patients with Resectable Pancreatic Adenocarcinoma.
Clinical cancer research : an official journal of the American Association for Cancer Research Mar, 2021 | Pubmed ID: 33277370
A feasibility study of combined epigenetic and vaccine therapy in advanced colorectal cancer with pharmacodynamic endpoint.
Clinical epigenetics Feb, 2021 | Pubmed ID: 33531075
Prognostic Implications of the Immune Tumor Microenvironment in Patients With Pancreatic and Gastrointestinal Neuroendocrine Tumors.
Pancreas May-Jun 01, 2021 | Pubmed ID: 34016898
Analysis of multispectral imaging with the AstroPath platform informs efficacy of PD-1 blockade.
Science (New York, N.Y.) Jun, 2021 | Pubmed ID: 34112666
Mismatch repair-deficient prostate cancer with parenchymal brain metastases treated with immune checkpoint blockade.
Cold Spring Harbor molecular case studies Aug, 2021 | Pubmed ID: 34140335
Endothelial Stromal PD-L1 (Programmed Death Ligand 1) Modulates CD8 T-Cell Infiltration After Heart Transplantation.
Circulation. Heart failure Oct, 2021 | Pubmed ID: 34555935
PD-L1 (Programmed Death Ligand 1) as a Marker of Acute Cellular Rejection After Heart Transplantation.
Circulation. Heart failure Oct, 2021 | Pubmed ID: 34558299
Neoadjuvant Cabozantinib and Nivolumab Converts Locally Advanced HCC into Resectable Disease with Enhanced Antitumor Immunity.
Nature cancer Sep, 2021 | Pubmed ID: 34796337
Multicenter randomized phase II trial of atezolizumab with or without cobimetinib in biliary tract cancers.
The Journal of clinical investigation Dec, 2021 | Pubmed ID: 34907910
Pancreatic Ductal Adenocarcinoma Cortical Mechanics and Clinical Implications.
Frontiers in oncology , 2022 | Pubmed ID: 35174086
Chemoradiation-induced alteration of programmed death-ligand 1, CD8+ tumor-infiltrating lymphocytes and mucin expression in rectal cancer.
Oncotarget , 2022 | Pubmed ID: 35937503
Multi-omic analyses of changes in the tumor microenvironment of pancreatic adenocarcinoma following neoadjuvant treatment with anti-PD-1 therapy.
Cancer cell Nov, 2022 | Pubmed ID: 36306792
Spatial transcriptomics analysis of neoadjuvant cabozantinib and nivolumab in advanced hepatocellular carcinoma identifies independent mechanisms of resistance and recurrence.
bioRxiv : the preprint server for biology Jan, 2023 | Pubmed ID: 36712023
Uncovering the spatial landscape of molecular interactions within the tumor microenvironment through latent spaces.
Cell systems Apr, 2023 | Pubmed ID: 37080163
A platform trial of neoadjuvant and adjuvant antitumor vaccination alone or in combination with PD-1 antagonist and CD137 agonist antibodies in patients with resectable pancreatic adenocarcinoma.
Nature communications Jun, 2023 | Pubmed ID: 37339979
Informing virtual clinical trials of hepatocellular carcinoma with spatial multi-omics analysis of a human neoadjuvant immunotherapy clinical trial.
bioRxiv : the preprint server for biology Aug, 2023 | Pubmed ID: 37645761
Spatial transcriptomics analysis of neoadjuvant cabozantinib and nivolumab in advanced hepatocellular carcinoma identifies independent mechanisms of resistance and recurrence.
Genome medicine Sep, 2023 | Pubmed ID: 37723590
Immune landscape of tertiary lymphoid structures in hepatocellular carcinoma (HCC) treated with neoadjuvant immune checkpoint blockade.
bioRxiv : the preprint server for biology Oct, 2023 | Pubmed ID: 37904980
Neoadjuvant radioimmunotherapy in pancreatic cancer enhances effector T cell infiltration and shortens their distances to tumor cells.
Science advances Feb, 2024 | Pubmed ID: 38324679
Mesothelin CAR T Cells Secreting Anti-FAP/Anti-CD3 Molecules Efficiently Target Pancreatic Adenocarcinoma and its Stroma.
Clinical cancer research : an official journal of the American Association for Cancer Research May, 2024 | Pubmed ID: 38393682
Comparing anti-tumor and anti-self immunity in a patient with melanoma receiving immune checkpoint blockade.
Journal of translational medicine Mar, 2024 | Pubmed ID: 38443917
Integration of Clinical Trial Spatial Multiomics Analysis and Virtual Clinical Trials Enables Immunotherapy Response Prediction and Biomarker Discovery.
Cancer research Aug, 2024 | Pubmed ID: 38861365
Semaphorin 3D promotes pancreatic ductal adenocarcinoma progression and metastasis through macrophage reprogramming.
Science advances Oct, 2024 | Pubmed ID: 39413197
Immunotherapy response induces divergent tertiary lymphoid structure morphologies in hepatocellular carcinoma.
Nature immunology Nov, 2024 | Pubmed ID: 39455893
Highly Multiplexed Immunofluorescence PhenoCycler Panel for Murine Formalin-Fixed Paraffin-Embedded Tissues Yields Insight Into Tumor Microenvironment Immunoengineering.
Laboratory investigation; a journal of technical methods and pathology Jan, 2025 | Pubmed ID: 39490742
Immune microenvironment of Epstein-Barr virus (EBV)-negative compared to EBV-associated gastric cancers: implications for immunotherapy.
Journal for immunotherapy of cancer Nov, 2024 | Pubmed ID: 39572160
CD137 agonism enhances anti-PD1 induced activation of expanded CD8 T cell clones in a neoadjuvant pancreatic cancer clinical trial.
iScience Jan, 2025 | Pubmed ID: 39811671
Deep immune profiling of intrahepatic cholangiocarcinoma with CODEX multiplexed imaging.
Hepatology communications Mar, 2025 | Pubmed ID: 39969434
Nivolumab and Relatlimab for the treatment of patients with unresectable or metastatic mismatch repair proficient colorectal cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research May, 2025 | Pubmed ID: 40388545
Sachin S. Surwase*,1,2,3,
Xin Ming M. Zhou*,3,4,
Kathryn M. Luly1,2,3,
Qingfeng Zhu5,6,7,
Niki Talebian6,
Robert A. Anders5,6,7,8,9,
Jordan J. Green1,2,3,5,8,9,10,11,12,
Stephany Y. Tzeng1,2,3,
Joel C. Sunshine1,3,4,5,6,8,9
1Department of Biomedical Engineering, Johns Hopkins University,
2Translational Tissue Engineering Center, Johns Hopkins University,
3Johns Hopkins Translational ImmunoEngineering Center, Johns Hopkins University,
4Department of Dermatology, Johns Hopkins University,
5Department of Oncology, Johns Hopkins University,
6Department of Pathology, Johns Hopkins University,
7Convergence Institute, Sidney Kimmel Comprehensive Cancer Center Johns Hopkins University School of Medicine,
8Bloomberg Kimmel Institute for Cancer Immunotherapy, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine,
9Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine,
10Institute for Nanobiotechnology, Johns Hopkins University,
11Departments of Neurosurgery and Ophthalmology, Johns Hopkins University School of Medicine,
12Departments of Materials Science & Engineering and Chemical & Biomolecular Engineering, Johns Hopkins University
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