Chapter 21
Drugs for Peptic Ulcer Disease
소화성 궤양 질환의 병태생리: 손상 요인
Peptic ulcers are sores in the mucosa of the stomach or duodenum.
The mucosal epithelium houses acid-secreting parietal and gastrin-secreting G cells.
The ...
소화성 궤양 질환의 병태생리: 점막 방어 요인
Peptic ulcer disease, or PUD, involves discontinuous gastrointestinal tract lining due to gastric acid or pepsin secretion.
The mucus-bicarbonate barrier ...
소화성 궤양 질환에 대한 산 억제제: 양성자 펌프 억제제
Two of the main contributors to peptic ulcer formation are H. pylori infections or NSAID use, both facilitating gastric acid production.
Gastric acid is ...
소화성 궤양 질환에 대한 산 억제제: 히스타민 H_2 수용체 길항제
Histamine H2 receptors are G protein-coupled receptors located on the basolateral membrane of parietal cells.
Histamine released from ECL cells binds to ...
소화성 궤양 질환에 대한 산 억제제: 제산제
In the gastric lumen, increased acid secretion can form or exacerbate ulcers in the mucosal layer.
Carbonate antacids, like sodium bicarbonate and calcium ...
소화성 궤양 질환 치료제: 점막 보호제로서의 수크랄페이트
Recall that increased acid secretion in the gastric lumen disrupts mucosal defense mechanisms and weakens the mucus-bicarbonate barrier.
This enables ...
소화성 궤양 질환에 대한 약물: 점막 보호제로서의 프로스타글란딘 유사체
The gastric mucosa majorly produces prostaglandin E2 and I2 to protect cells from mucosal injury.
These bind to EP3 receptors, which couple with ...
소화성 궤양에서 헬리코박터 파일로리 치료: 항균 요법
Helicobacter pylori or H. pylori, a gram-negative bacillus, thrives in the stomach's acidic environment, impairing somatostatin production. This ...
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