Chapter 8
Nonlinear Pharmacokinetics
Farmacocinetica non lineare: Panoramica
Nonlinear pharmacokinetics, or dose-dependent kinetics, manifests when certain drugs deviate from linear behavior at higher doses, not to follow ...
Farmacocinetica non lineare: cause di non linearità
Various factors contribute to nonlinearity in drug pharmacokinetics.
Nonlinearity in drug absorption may result from rate-limited solubility, ...
Farmacocinetica non lineare: equazione di Michaelis-Menten
The Michaelis-Menten equation describes capacity-limited kinetics in drug metabolism.
It determines the rate of decline of drug concentration over time, ...
Determinazione della costante di Michaelis e del tasso di eliminazione massimo
The Michaelis-Menten equation parameters–Michaelis constant, KM, and the maximum process rate, Vmax – are estimated post-drug administration.
...
Farmacocinetica non lineare: eliminazione dei farmaci per l'iniezione in bolo endovenoso
In capacity-limited pharmacokinetics, drug elimination is influenced by Vmax and KM.
Following an IV bolus, Dt, the amount of drug in the body at any ...
Distribuzione di farmaci come modello a un compartimento ed eliminazione mediante farmacocinetica non lineare: panoramica
Drug administration through various routes results in mixed drug elimination, involving both nonlinear and linear processes.
The metabolism of drugs ...
Parametri che influenzano l'eliminazione non lineare: input di ordine zero, assorbimento del primo ordine e modello a due compartimenti
Drugs administered through different administration routes follow nonlinear elimination.
Consider a drug administered through a constant IV infusion, ...
Farmacocinetica non lineare: dipendenza dell'emivita di eliminazione e della clearance della dose
Drug elimination half-life and clearance vary with dosage or concentration in nonlinear kinetics.
The elimination half-life is influenced by the ...
Cronofarmacocinetica: ritmi circadiani e influenza sulla risposta ai farmaci
Circadian rhythms influence cyclic changes in plasma drug concentrations through regular fluctuations in physiological functions.
Standard circadian ...
Cronofarmacocinetica: farmacocinetica tempo-dipendente
Chronopharmacokinetics studies the temporal change in drug absorption and elimination, whether cyclical or noncyclical.
Cyclic changes occur over constant ...
Farmacocinetica non lineare: biodisponibilità e legame proteina-farmaco
For drugs that follow nonlinear pharmacokinetics, the absorption, distribution, and elimination processes may potentially saturate.
A saturable pathway ...
Farmacocinetica non lineare: ruolo dei trasportatori
Drug kinetics, under nonlinear changes influenced by transporter proteins, are pivotal in drug distribution.
These cellular transporters in cells modulate ...
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