Chapter 8
Nonlinear Pharmacokinetics
Pharmacocinétique non linéaire : aperçu
Nonlinear pharmacokinetics, or dose-dependent kinetics, manifests when certain drugs deviate from linear behavior at higher doses, not to follow ...
Pharmacocinétique non linéaire : causes de la non-linéarité
Various factors contribute to nonlinearity in drug pharmacokinetics.
Nonlinearity in drug absorption may result from rate-limited solubility, ...
Pharmacocinétique non linéaire : équation de Michaelis-Menten
The Michaelis-Menten equation describes capacity-limited kinetics in drug metabolism.
It determines the rate of decline of drug concentration over time, ...
Détermination de la constante de Michaelis et du taux d’élimination maximal
The Michaelis-Menten equation parameters–Michaelis constant, KM, and the maximum process rate, Vmax – are estimated post-drug administration.
...
Pharmacocinétique non linéaire : élimination de médicaments pour l’injection de bolus IV
In capacity-limited pharmacokinetics, drug elimination is influenced by Vmax and KM.
Following an IV bolus, Dt, the amount of drug in the body at any ...
Distribution de médicaments en tant que modèle à un compartiment et élimination par pharmacocinétique non linéaire : aperçu
Drug administration through various routes results in mixed drug elimination, involving both nonlinear and linear processes.
The metabolism of drugs ...
Paramètres affectant l’élimination non linéaire : entrée d’ordre zéro, absorption du premier ordre et modèle à deux compartiments
Drugs administered through different administration routes follow nonlinear elimination.
Consider a drug administered through a constant IV infusion, ...
Pharmacocinétique non linéaire : dépendance de la demi-vie d’élimination et de la clairance de la dose
Drug elimination half-life and clearance vary with dosage or concentration in nonlinear kinetics.
The elimination half-life is influenced by the ...
Chronopharmacocinétique : rythmes circadiens et influence sur la réponse aux médicaments
Circadian rhythms influence cyclic changes in plasma drug concentrations through regular fluctuations in physiological functions.
Standard circadian ...
Chronopharmacocinétique : pharmacocinétique dépendante du temps
Chronopharmacokinetics studies the temporal change in drug absorption and elimination, whether cyclical or noncyclical.
Cyclic changes occur over constant ...
Pharmacocinétique non linéaire : biodisponibilité et liaison protéine-médicament
For drugs that follow nonlinear pharmacokinetics, the absorption, distribution, and elimination processes may potentially saturate.
A saturable pathway ...
Pharmacocinétique non linéaire : rôle des transporteurs
Drug kinetics, under nonlinear changes influenced by transporter proteins, are pivotal in drug distribution.
These cellular transporters in cells modulate ...
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