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Chapter 26

The Cytoskeleton II: Microtubules and Intermediate Filaments

Microtubules
Microtubules
Microtubules are the thickest cytoskeletal filaments with a diameter of 25 nm. In prokaryotic organisms, microtubules are commonly found in locomotory ...
Instabilité des microtubules
Instabilité des microtubules
Microtubules are hollow cylindrical filaments having a diameter of approximately 25 nm and a length that varies from 200 nm to 25 μm. GTP-bound ...
Formation des microtubules
Formation des microtubules
Microtubules are dynamic structures that undergo continuous assembly and disassembly. They originate from specialized multi-protein complexes known as ...
Protéines associées aux microtubules (MAP)
Protéines associées aux microtubules (MAP)
Microtubule function and architecture are regulated by an array of specialized proteins called microtubule-associated proteins or MAPs. These proteins are ...
Déstabilisation des microtubules
Déstabilisation des microtubules
The destabilization of microtubules can occur during different stages of the microtubule lifecycle, such as nucleation or elongation. It can take place at ...
Protéines motrices associées aux microtubules
Protéines motrices associées aux microtubules
Eukaryotic cells have different motor proteins for transporting various cargo within the cell. These motor proteins differ based on the filament they ...
Le mouvement des organites et des vésicules
Le mouvement des organites et des vésicules
In eukaryotic cells,  cytoskeletal filaments such as actin, microtubules, and intermediate filaments form a mesh-like cytoskeletal network. These ...
Assemblage de structures complexes de microtubules
Assemblage de structures complexes de microtubules
Complex microtubule structures are present in resting cells and in dividing cells. In resting cells, they are responsible for maintaining the cellular ...
Microtubules dans la motilité cellulaire
Microtubules dans la motilité cellulaire
Microtubules are thick hollow cylindrical proteins that help form the cytoskeleton. Microtubules have varied roles in the cell. These filaments help form ...
Mécanisme du mouvement ciliaire
Mécanisme du mouvement ciliaire
The ciliary structures were first seen in 1647 by Antonie Leeuwenhoek while observing the protozoans. In lower organisms, these appendages are responsible ...
Microtubules dans la signalisation
Microtubules dans la signalisation
The primary cilium, made up of microtubules, acts as antennae on the cell surfaces for relaying external stimuli into the cells. These fine hair-like ...
Médicaments qui stabilisent les microtubules
Médicaments qui stabilisent les microtubules
Microtubules are dynamic structures that undergo cycles of catastrophe and rescue. The microtubules play a central role in cell division by forming the ...
Médicaments qui déstabilisent les microtubules
Médicaments qui déstabilisent les microtubules
Microtubules are dynamic structures and can be regulated by microtubule targeting agents (MTAs). Microtubule destabilizing drugs are a class of MTAs that ...
La structure des filaments intermédiaires
La structure des filaments intermédiaires
The intermediate filaments are one of three widely studied cytoskeletal filaments. They are so named as their diameter (10 nm) is in between that of ...
Types de filaments intermédiaires
Types de filaments intermédiaires
The intermediate filaments are an essential component of the cytoskeleton. Presently six types of intermediate filament have been identified. Type I and ...
Formation de filaments intermédiaires
Formation de filaments intermédiaires
Intermediate filaments are cytoskeletal proteins with higher tensile strength and flexibility than microfilaments and microtubules. Unlike the other two ...
Démontage des filaments intermédiaires
Démontage des filaments intermédiaires
Intermediate filaments (IFs) do not undergo spontaneous disassembly. Enzymes, kinases, and phosphatases add and remove phosphates from specific sites to ...
Septines
Septines
Septins are protein filaments forming the cytoskeleton along with the microtubules, microfilaments, intermediate filaments, and other accessory proteins. ...
Rôle des septines
Rôle des septines
Septins are the recently discovered fourth major protein component of the cytoskeleton, along with microfilaments, microtubules, and intermediate ...
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