Disruption of the Mouse Blood-Brain Barrier by Small Extracellular Vesicles from Hypoxic Human Placentas
733 Views
•
05:31 min
•
January 26th, 2024
DOI :
January 26th, 2024
•Hermes Sandoval*1, José León*1,2, Felipe Troncoso1, Valeria de la Hoz3, Aaron Cisterna3,4, Moisés Contreras1, Fidel O. Castro5, Belén Ibañez1, Jesenia Acurio1, Carlos Escudero1,6
1Vascular Physiology Laboratory, Department of Basic Sciences, Universidad del Bío-Bío, Chillan, 2Nursery School, Health Faculty, Universidad Santo Tomás, Los Angeles, 3Obstetrics and Gynecology Department, Herminda Martin Clinical Hospital, Chillan, 4Faculty of Medicine, Universidad Católica de la Santísima Concepción, Concepcion, 5Laboratory of Animal Biotechnology, Department of Animal Science, Faculty of Veterinary Sciences, Universidad de Concepción, Chillan, 6Group of Research and Innovation in Vascular Health (GRIVAS Health), Chillan
Chapters in this video
0:00
Introduction
1:19
Isolation of Normoxic and Hypoxic Human Placenta‐Derived Small Extracellular Vesicles for Injection into Mice
2:51
Injecting Human Placenta‐Derived Small Extracellular Vesicles into Mice to Study BBB Disruption
Related Videos
08:37
Intravital Microscopy of the Mouse Brain Microcirculation using a Closed Cranial Window
17.4K Views
12:02
Human Primary Trophoblast Cell Culture Model to Study the Protective Effects of Melatonin Against Hypoxia/reoxygenation-induced Disruption
15.8K Views
07:39
Mouse In Vivo Placental Targeted CRISPR Manipulation
2.5K Views
09:48
Quantification of Neurovascular Protection Following Repetitive Hypoxic Preconditioning and Transient Middle Cerebral Artery Occlusion in Mice
13.7K Views
07:36
Modeling Encephalopathy of Prematurity Using Prenatal Hypoxia-ischemia with Intra-amniotic Lipopolysaccharide in Rats
11.3K Views
04:17
Ex Vivo Placental Explant Flow Culture - Mimicking the Dynamic Conditions In Utero
1.2K Views
10:12
Neisseria meningitidis Infection of Induced Pluripotent Stem-Cell Derived Brain Endothelial Cells
2.3K Views
08:04
Derivation, Expansion, Cryopreservation and Characterization of Brain Microvascular Endothelial Cells from Human Induced Pluripotent Stem Cells
6.3K Views
05:19
Evaluation of Blood-Brain Barrier Breakdown in a Mouse Model of Mild Traumatic Brain Injury
532 Views
09:35
A Mouse Model of Hemorrhagic Transformation Induced by Acute Hyperglycemia Combined with Transient Focal Ischemia
304 Views
Copyright © 2025 MyJoVE Corporation. All rights reserved