Development of a 68Gallium-Labeled D-Peptide PET Tracer for Imaging Programmed Death-Ligand 1 Expression
1.4K Views
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09:06 min
•
February 3rd, 2023
DOI :
February 3rd, 2023
•Lulu Zhang*1, Siqi Zhang*2, Wenyu Wu1, Xingkai Wang2, Jieting Shen2, Dongyuan Wang4, Kuan Hu*2,3, Ming-Rong Zhang*3, Feng Wang*1, Rui Wang*2
1Department of Nuclear Medicine, Nanjing First Hospital, Nanjing Medical University, 2State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, 3Department of Advanced Nuclear Medicine Sciences, Institute for Quantum Medical Science, National Institutes for Quantum Science and Technology, 4Department of Pharmacy, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Chapters in this video
0:00
Introduction
1:09
68Ga Radiolabeling
1:58
Tracer Stability Test
3:01
Cellular Uptake Experiment
4:33
Positron Emission Tomography (PET) Imaging
5:50
Ex Vivo Biodistribution
6:42
Results: Analyzing In Vivo Binding Affinity, Stability, and Imaging Capacity of [68Ga]DPA
8:38
Conclusion
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