A Chronic Sleep Fragmentation Model using Vibrating Orbital Rotor to Induce Cognitive Deficit and Anxiety-Like Behavior in Young Wild-Type Mice

5.2K Views

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06:23 min

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September 22nd, 2020

DOI :

10.3791/61531-v

September 22nd, 2020

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Yi Xie¹, Sai-Yue Deng¹, Si-Miao Chen¹, Xue-Jiao Chen¹, Wen-Wen Lai¹, Li-Fang Huang¹, Li Ba¹, Wei Wang¹^,², Feng-Fei Ding¹^,³

¹Department of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430000, China, ²Key Laboratory of Neurological Diseases of Chinese Ministry of Education, The School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430000,China, ³Department of Pharmacology, School of Basic Medical Science; State Key Laboratory of Medical Neurobiology, Institutes of Brain Science and Collaborative Innovation Center for Brain Science, Fudan University, Shanghai 200032, China

Summary

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Chronic Sleep Fragmentation

Vibrating Orbital Rotor

Cognitive Deficit

Anxiety like Behavior

Wild type Mice

Neurodegenerative Disease

Sleep Disturbance Model

Behavioral Outcomes

Alzheimer s Disease

Morris Water Maze Test

Experimental Protocol

Cage Environment

Rotational Motion

Chronic Sleep Disturbance Impacts

Chapters in this video

0:04

Introduction

1:06

Mouse Screening Preparation

1:58

Chronic Sleep Fragmentation (CSF) Modeling

3:04

Morris Water Maze (MWM) Test

4:00

Results: Representative Effects of CSF Modeling on Young Wild-Type Mouse Cognitive Abilities and Anxiety-Like Behaviors

5:34

Conclusion

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