JoVE Logo

Oturum Aç

6.25 : Hepatic Drug Clearance: Role of Transporters

In the liver and bile canaliculi, influx and efflux transporters modification can influence intrinsic clearance. Transporters play a significant role in moving drugs within liver cells. Elaborate models, such as the Biopharmaceutical Classification System (BCS), are essential to relate transporters to drug disposition. This system categorizes drugs into four classes based on solubility and permeability, providing insights into elimination routes and the effects of transporters following oral and intravenous administration.

  1. Class I: Drugs with high solubility and high permeability, resulting in efficient absorption and minimal transporter influence (e.g., metoprolol, propranolol, and amoxicillin).
  2. Class II: Drugs with low solubility but high permeability, where efflux transporters can significantly limit absorption and pump drugs into bile (e.g., ezetimibe, ibuprofen, and ketoconazole).
  3. Class III: Drugs with high solubility but low permeability, where uptake transporters may enhance absorption (e.g., cimetidine, cephalexin, and ranitidine).
  4. Class IV: Drugs with low solubility and permeability. They often exhibit poor bioavailability due to dual limitations (e.g., itraconazole, chlorothiazide, and furosemide).

By integrating solubility and permeability, the Biopharmaceutical Classification System highlights how transporters influence drug disposition; for instance, Class II drugs face significant challenges due to efflux into the gastrointestinal lumen and biliary excretion.

Etiketler

Hepatic Drug ClearanceTransportersIntrinsic ClearanceBiopharmaceutical Classification System BCSDrug DispositionSolubilityPermeabilityClass I DrugsClass II DrugsClass III DrugsClass IV DrugsAbsorptionEfflux TransportersUptake TransportersBioavailability

Bölümden 6:

article

Now Playing

6.25 : Hepatic Drug Clearance: Role of Transporters

Pharmacokinetics: Drug Excretion and Clearance

42 Görüntüleme Sayısı

article

6.1 : Drug Elimination: Overview

Pharmacokinetics: Drug Excretion and Clearance

1.1K Görüntüleme Sayısı

article

6.2 : Elimination Kinetics: First-Order and Zero-Order

Pharmacokinetics: Drug Excretion and Clearance

496 Görüntüleme Sayısı

article

6.3 : Renal Drug Excretion: Overview

Pharmacokinetics: Drug Excretion and Clearance

126 Görüntüleme Sayısı

article

6.4 : Renal Drug Excretion: Glomerular Filtration

Pharmacokinetics: Drug Excretion and Clearance

182 Görüntüleme Sayısı

article

6.5 : Renal Drug Excretion: Tubular Reabsorption

Pharmacokinetics: Drug Excretion and Clearance

121 Görüntüleme Sayısı

article

6.6 : Renal Drug Excretion: Tubular Secretion

Pharmacokinetics: Drug Excretion and Clearance

147 Görüntüleme Sayısı

article

6.7 : Renal Drug Excretion: Effect of Urine pH, Flow Rate, and Drug pKa

Pharmacokinetics: Drug Excretion and Clearance

142 Görüntüleme Sayısı

article

6.8 : Hepatic Drug Excretion: Enterohepatic Cycling

Pharmacokinetics: Drug Excretion and Clearance

1.1K Görüntüleme Sayısı

article

6.9 : Hepatic Drug Excretion: Influencing Factors

Pharmacokinetics: Drug Excretion and Clearance

95 Görüntüleme Sayısı

article

6.10 : Drug Excretion: Pulmonary and Glandular Routes

Pharmacokinetics: Drug Excretion and Clearance

89 Görüntüleme Sayısı

article

6.11 : Drug Excretion: Miscellaneous Routes

Pharmacokinetics: Drug Excretion and Clearance

49 Görüntüleme Sayısı

article

6.12 : Drug Clearance: Overview

Pharmacokinetics: Drug Excretion and Clearance

59 Görüntüleme Sayısı

article

6.13 : Clearance Models: Physiological Models

Pharmacokinetics: Drug Excretion and Clearance

53 Görüntüleme Sayısı

article

6.14 : Clearance Models: Compartment Models

Pharmacokinetics: Drug Excretion and Clearance

55 Görüntüleme Sayısı

See More

JoVE Logo

Gizlilik

Kullanım Şartları

İlkeler

Araştırma

Eğitim

JoVE Hakkında

Telif Hakkı © 2020 MyJove Corporation. Tüm hakları saklıdır