JoVE Logo

Oturum Aç

6.11 : Drug Excretion: Miscellaneous Routes

Drug excretion involves various organs, including the liver, intestines, skin, and eyes. In the case of drugs or toxins, they can be actively secreted into bile by transporters in the hepatocyte's canalicular membrane. These substances enter the GI tract during digestion and may be reabsorbed into the body from the intestine. This process, known as enterohepatic recycling, can significantly prolong the presence and effects of a substance in the body. To interrupt this cycle, specific substances can be administered orally to bind metabolites excreted in the bile, with unabsorbed drugs and biliary excretions being eliminated in the feces.

Excretion through skin, saliva, and tears is quantitatively unimportant. Similarly, excretion into hair is also insignificant, although detecting drugs in these tissues can have forensic implications. Basic compounds may be slightly concentrated in more acidic fluids like milk, while acidic compounds will have lower concentrations. Non-electrolytes like ethanol and urea readily enter breast milk, reaching the same concentration as in plasma. Drugs administered to breastfeeding women can expose the infant to the medication or its metabolites, necessitating caution.

Etiketler

Drug ExcretionLiverIntestinesSkinEyesHepatocyteCanalicular MembraneEnterohepatic RecyclingMetabolitesBileFecesForensic ImplicationsBreast MilkBreastfeedingDrug Concentration

Bölümden 6:

article

Now Playing

6.11 : Drug Excretion: Miscellaneous Routes

Pharmacokinetics: Drug Excretion and Clearance

49 Görüntüleme Sayısı

article

6.1 : Drug Elimination: Overview

Pharmacokinetics: Drug Excretion and Clearance

1.1K Görüntüleme Sayısı

article

6.2 : Elimination Kinetics: First-Order and Zero-Order

Pharmacokinetics: Drug Excretion and Clearance

496 Görüntüleme Sayısı

article

6.3 : Renal Drug Excretion: Overview

Pharmacokinetics: Drug Excretion and Clearance

126 Görüntüleme Sayısı

article

6.4 : Renal Drug Excretion: Glomerular Filtration

Pharmacokinetics: Drug Excretion and Clearance

182 Görüntüleme Sayısı

article

6.5 : Renal Drug Excretion: Tubular Reabsorption

Pharmacokinetics: Drug Excretion and Clearance

121 Görüntüleme Sayısı

article

6.6 : Renal Drug Excretion: Tubular Secretion

Pharmacokinetics: Drug Excretion and Clearance

147 Görüntüleme Sayısı

article

6.7 : Renal Drug Excretion: Effect of Urine pH, Flow Rate, and Drug pKa

Pharmacokinetics: Drug Excretion and Clearance

142 Görüntüleme Sayısı

article

6.8 : Hepatic Drug Excretion: Enterohepatic Cycling

Pharmacokinetics: Drug Excretion and Clearance

1.1K Görüntüleme Sayısı

article

6.9 : Hepatic Drug Excretion: Influencing Factors

Pharmacokinetics: Drug Excretion and Clearance

95 Görüntüleme Sayısı

article

6.10 : Drug Excretion: Pulmonary and Glandular Routes

Pharmacokinetics: Drug Excretion and Clearance

89 Görüntüleme Sayısı

article

6.12 : Drug Clearance: Overview

Pharmacokinetics: Drug Excretion and Clearance

59 Görüntüleme Sayısı

article

6.13 : Clearance Models: Physiological Models

Pharmacokinetics: Drug Excretion and Clearance

53 Görüntüleme Sayısı

article

6.14 : Clearance Models: Compartment Models

Pharmacokinetics: Drug Excretion and Clearance

55 Görüntüleme Sayısı

article

6.15 : Clearance Models: Noncompartmental Models

Pharmacokinetics: Drug Excretion and Clearance

45 Görüntüleme Sayısı

See More

JoVE Logo

Gizlilik

Kullanım Şartları

İlkeler

Araştırma

Eğitim

JoVE Hakkında

Telif Hakkı © 2020 MyJove Corporation. Tüm hakları saklıdır