Chapter 7
Pharmacokinetic Models
Farmakokinetik Verilerin Analiz Yöntemleri: Model ve Model Bağımsız Yaklaşımlar
The drug disposition in the body is a complex process and can be studied using two major approaches: the model and the model-independent approaches.
The ...
Farmakokinetik Veriler için Model Yaklaşımları: Kompartman Modelleri
Compartmental analysis is a commonly used approach to characterize drug pharmacokinetics.
Compartment models assume the body as a series of reversibly ...
IV Bolus Uygulaması için Tek Bölmeli Açık Model: Genel Hususlar
A one-compartment open pharmacokinetic model describes the drug concentration-time course in the body post-administration. It views the body as a single, ...
IV Bolus Uygulaması için Tek Bölmeli Açık Model: Eliminasyon Hızı Sabiti, Yarılanma Ömrü ve Dağılım Hacminin Tahmini
The one-compartment open model for IV bolus drug administration considers drug elimination as a monoexponential process.
Analyzing the plasma drug ...
IV Bolus Uygulaması için Tek Bölmeli Açık Model: Boşluk Tahmini
Clearance signifies the theoretical fluid volume from which a drug is completely removed within a specific timeframe, expressed as volume per unit time. ...
Tek bölmeli model: IV infüzyon
IV infusion is suitable when maintenance of constant and stable drug concentration in the body is desired or when the drug poses toxicity risks.
For ...
Ekstravasküler Uygulama için Tek Bölmeli Açık Model: Sıfır Mertebeden Absorpsiyon Modeli
Extravascular drug administration occurs via oral, intramuscular, or rectal routes.
It relies on absorption for the drug's therapeutic activity.
Here, ...
Ekstravasküler Uygulama için Tek Bölmeli Açık Model: Birinci Dereceden Absorpsiyon Modeli
The first-order absorption model for extravascular administration considers the rate at which a drug is absorbed, distributed in body tissues, and ...
Tek Bölmeli Açık Model: ka Tahmini için Wagner-Nelson ve Loo Riegelman Yöntemi
The Wagner-Nelson method estimates the absorption rate constant, ka, for drugs administered without assuming zero- or first-order absorption.
Its ...
Tek Bölmeli Açık Model: İdrar Boşaltım Verileri ve k
Urinary excretion data helps understand the process of drug elimination from the body, providing insight into the clearance of unaltered drugs.
It is a ...
Çok bölmeli modeller: genel bakış
Multicompartment models illustrate how drugs are distributed and eliminated within the body. They offer a more accurate depiction than one-compartment ...
İki bölmeli açık model: genel bakış
Multicompartment pharmacokinetic models illustrate drug distribution and elimination within the body.
The most common type of these models is the ...
İki bölmeli açık model: IV bolus uygulaması
The two-compartment model for intravenous bolus administration comprises central and peripheral compartments, representing the distribution of a drug in ...
İki bölmeli açık model: IV infüzyon
Two-compartment models are pharmacokinetic tools to understand drug distribution.
For a drug administered via a constant rate or zero-order intravenous ...
İki bölmeli açık model: ekstravasküler uygulama
Two-compartment models for extravascular administration involve a central and a peripheral compartment.
For a drug entering the body via a first-order ...
Üç Bölmeli Açık Model
Three-compartment models are similar to the two-compartment model but have an additional deep tissue compartment.
The deep tissue compartment represents ...
Mekanistik Modeller: Bölme Modellerine Genel Bakış
Pharmacokinetic models can be classified as empirical or mechanistic.
Empirical models include data description with minimal assumptions about the ...
Mekanistik Modeller: Birey ve Popülasyon Analizinde Bölme Modelleri
The individual analysis uses mechanistic models involving single-source data. However, data collection errors prevent perfect observed data prediction.
In ...
Mekanistik Modeller: Sayısal Problem Çözümü için Algoritmalarda Bölme Modelleri
Mechanistic models use numerical problem-solving algorithms to evaluate parameters.
Some algorithms use linearization techniques to simplify the model ...
Farmakokinetik Veriler için Model Yaklaşımları: Fizyolojik Modeller
Physiological models illustrate the drug's distribution and elimination processes within the body.
They describe the drug concentration in target ...
Fizyolojik Farmakokinetik Modeller: Protein Bağlanmalı Varsayım
Physiological models can predict drug disposition assuming linear drug-protein interactions.
Compared to conventional models, they effectively predict ...
Fizyolojik Farmakokinetik Modeller: Kan Akışı Sınırlı ve Difüzyon Sınırlı Modeller
Physiological models generally postulate a swift drug distribution between tissue and venous blood.
Rapid drug equilibrium assumes quick drug diffusion ...
Fizyolojik Farmakokinetik Modeller: Hepatik Taşıyıcı Aracılı Klerensi İçerme
Drug transporters are pivotal in drug absorption, distribution, and excretion processes and should be included in physiologically-based pharmacokinetic ...
Farmakokinetik Veriler için Model Yaklaşımları: Dağıtık Parametre Modelleri
Pharmacokinetic models employ mathematical expressions for predicting drug behavior in the body and calculating pharmacokinetic parameters.
Different ...
Farmakokinetik Veriler için Modelden Bağımsız Yaklaşımlar: Bölmeli Olmayan Analiz
Noncompartmental analysis is an alternative method for describing drug pharmacokinetics without assigning a particular compartmental model to the drug.
...
Bölmeli Olmayan Analiz: İstatistiksel Moment Teorisi
Noncompartmental analyses rely on statistical moment theory to examine time-related changes in macroscopic events. Mean residence time, MRT, describes the ...
Bölmeli Olmayan Analiz: Ortalama Kalış Süresi
According to statistical moment theory, mean residence time is the expected mean of a probability density function distribution. It can also be viewed ...
Bölmeli Olmayan Analiz: Ortalama Geçiş, Absorpsiyon ve Çözünme Süresi
When drugs are administered extravascularly, various parameters are considered for noncompartmental analysis.
The mean transit time, MTT, is the total ...
Bölmeli Olmayan Analiz: Çeşitli Farmakokinetik Parametreler
The noncompartmental approach utilizes various factors, including clearance, bioavailability, and total volume of distribution.
Once a drug is ...
Farmakokinetik Modeller: Karşılaştırma ve Seçim Kriteri
Physiological and compartmental models used to study biological systems rely on differential equations for mass balance.
Physiological models consider ...
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