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Core - Cell Biology

    Chapter 22

    Signaling Networks of G Protein-coupled Receptors

    22.1 : G Protein-coupled Receptors01:15

    22.1 : G Protein-coupled Receptors

    G Protein-Coupled Receptors or GPCRs are membrane-bound receptors that transiently associate with heterotrimeric G proteins and induce an appropriate ...

    11.3K views
    22.2 : Activation and Inactivation of G Proteins01:22

    22.2 : Activation and Inactivation of G Proteins

    Heterotrimeric G proteins are guanine nucleotide-binding proteins. As the name suggests, heterotrimeric G proteins are composed of three subunits: alpha, ...

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    22.3 : GPCR Desensitization01:12

    22.3 : GPCR Desensitization

    G protein-coupled receptor (GPCR) signaling plays a crucial role in cell functioning. GPCR desensitization is an equally essential process. It allows ...

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    22.4 : G-Protein Gated Ion Channels01:21

    22.4 : G-Protein Gated Ion Channels

    GPCRs are primarily responsible for our sense of smell, taste, and vision.  The binding of a sensory stimulus activates GPCR to stimulate effector ...

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    22.5 : GPCRs Regulate Adenylyl Cylase Activity01:09

    22.5 : GPCRs Regulate Adenylyl Cylase Activity

    Some GPCRs transmit signals through adenylyl cyclase (AC), a transmembrane enzyme. AC helps synthesize second messenger cyclic adenosine monophosphate ...

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    22.6 : cAMP-dependent Protein Kinase Pathways01:25

    22.6 : cAMP-dependent Protein Kinase Pathways

    Cyclic Adenosine Monophosphate (cAMP) is an essential second messenger that activates protein kinase A (PKA) and regulates various biological processes. A ...

    6.1K views
    22.7 : IP3/DAG Signaling Pathway01:11

    22.7 : IP3/DAG Signaling Pathway

    Membrane lipids such as phosphatidylinositol (PI) are precursors for several membrane-bound and soluble second messengers. Specific kinases phosphorylate ...

    11.9K views
    22.8 : Feedback Regulation of Calcium Concentration01:27

    22.8 : Feedback Regulation of Calcium Concentration

    Calcium is an essential signaling molecule required for various cellular functions. Calcium pumps and ion channels on cell and organellar membranes, such ...

    3.3K views
    22.9 : Calmodulin-dependent Signaling01:16

    22.9 : Calmodulin-dependent Signaling

    Calmodulin (CaM) is a calcium-binding protein in eukaryotes that controls various calcium-regulated cellular processes. It has four calcium-binding sites ...

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    22.10 : Nitric Oxide Signaling Pathway01:28

    22.10 : Nitric Oxide Signaling Pathway

    Nitric oxide (NO), an inorganic gas, acts as a potent second messenger in most animal and plant tissues. NO diffuses out of the cells that produce it ...

    4.9K views
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