Robert J. Coffey

Targeting transforming growth factor alpha expression to discrete loci of the neuroendocrine brain induces female sexual precocity.

K-Ras-independent effects of the farnesyl transferase inhibitor L-744,832 on cyclin B1/Cdc2 kinase activity, G2/M cell cycle progression and apoptosis in human pancreatic ductal adenocarcinoma cells.

Targeted disruption of the Kvlqt1 gene causes deafness and gastric hyperplasia in mice.

Overexpression of heparin-binding EGF-like growth factor in mouse pancreas results in fibrosis and epithelial metaplasia.

Stromal production of prostacyclin confers an antiapoptotic effect to colonic epithelial cells.

Dysregulation of E-cadherin by oncogenic Ras in intestinal epithelial cells is blocked by inhibiting MAP kinase.

Myristoylated Naked2 escorts transforming growth factor alpha to the basolateral plasma membrane of polarized epithelial cells.

Oncogenic Ras dominates overexpression of E-cadherin in malignant transformation of intestinal epithelial cells.

Identification of MAGI-3 as a transforming growth factor-alpha tail binding protein.

Keratin 19 gene drives Cre recombinase expression throughout the early postimplantation mouse embryo.

Amphiregulin causes functional downregulation of adherens junctions in psoriasis.

Differential effects of amphiregulin and TGF-alpha on the morphology of MDCK cells.

Lysophosphatidic acid, a disintegrin and metalloprotease-17 and heparin-binding epidermal growth factor-like growth factor in ovarian cancer: the first word, not the last.

Ligand-dependent activation of the epidermal growth factor receptor by secondary bile acids in polarizing colon cancer cells.

Oncogenic KRAS provides a uniquely powerful and variable oncogenic contribution among RAS family members in the colonic epithelium.

Ménétrier disease and gastrointestinal stromal tumors: hyperproliferative disorders of the stomach.

Variability of in situ proteomic profiling and implications for study design in colorectal tumors.

Naked2 acts as a cargo recognition and targeting protein to ensure proper delivery and fusion of TGF-alpha containing exocytic vesicles at the lower lateral membrane of polarized MDCK cells.

Zebrafish Naked1 and Naked2 antagonize both canonical and non-canonical Wnt signaling.

Lrp6 is required for convergent extension during Xenopus gastrulation.

TACE/ADAM-17: a component of the epidermal growth factor receptor axis and a promising therapeutic target in colorectal cancer.

EGF receptor-independent action of TGF-alpha protects Naked2 from AO7-mediated ubiquitylation and proteasomal degradation.

Multiple mechanisms are responsible for transactivation of the epidermal growth factor receptor in mammary epithelial cells.

Molecular imaging of therapeutic response to epidermal growth factor receptor blockade in colorectal cancer.

ERBBs in the gastrointestinal tract: recent progress and new perspectives.

Identification of early intestinal neoplasia protein biomarkers using laser capture microdissection and MALDI MS.

The enterocyte microvillus is a vesicle-generating organelle.

Transmembrane and soluble isoforms of heparin-binding epidermal growth factor-like growth factor regulate distinct processes in the pancreas.

Novel association of APC with intermediate filaments identified using a new versatile APC antibody.

p120-catenin is essential for maintenance of barrier function and intestinal homeostasis in mice.

Volume of preclinical xenograft tumors is more accurately assessed by ultrasound imaging than manual caliper measurements.

Distinguishing Ménétrier's disease from its mimics.

Dual blockade of the EGFR and COX-2 pathways: a phase II trial of cetuximab and celecoxib in patients with chemotherapy refractory metastatic colorectal cancer.

Naked1 antagonizes Wnt signaling by preventing nuclear accumulation of β-catenin.

Amphiregulin exosomes increase cancer cell invasion.

Adenoma formation following limited ablation of p120-catenin in the mouse intestine.

Enterocyte microvillus-derived vesicles detoxify bacterial products and regulate epithelial-microbial interactions.

The pan-ErbB negative regulator Lrig1 is an intestinal stem cell marker that functions as a tumor suppressor.

[18F]FLT-PET to predict pharmacodynamic and clinical response to cetuximab therapy in Ménétrier's disease.

Myofibroblast keratinocyte growth factor reduces tight junctional integrity and increases claudin-2 levels in polarized Caco-2 cells.

Proteomic analysis of exosomes from mutant KRAS colon cancer cells identifies intercellular transfer of mutant KRAS.

3'-Deoxy-3'-18F-fluorothymidine PET predicts response to (V600E)BRAF-targeted therapy in preclinical models of colorectal cancer.

Helicobacter pylori promotes the expression of Krüppel-like factor 5, a mediator of carcinogenesis, in vitro and in vivo.

Heparin-binding epidermal growth factor-like growth factor eliminates constraints on activated Kras to promote rapid onset of pancreatic neoplasia.

Pathology of rodent models of intestinal cancer: progress report and recommendations.

Limits of [18F]-FLT PET as a biomarker of proliferation in oncology.

Extracellular vesicles: communication, coercion, and conditioning.

Transformation of polarized epithelial cells by apical mistrafficking of epiregulin.

Malignant transformation of colonic epithelial cells by a colon-derived long noncoding RNA.

Trafficking of epidermal growth factor receptor ligands in polarized epithelial cells.

Global phosphotyrosine proteomics identifies PKCδ as a marker of responsiveness to Src inhibition in colorectal cancer.

A peptide-based positron emission tomography probe for in vivo detection of caspase activity in apoptotic cells.

From wavy hair to naked proteins: the role of transforming growth factor alpha in health and disease.

Excess PLAC8 promotes an unconventional ERK2-dependent EMT in colon cancer.

Inducible loss of one Apc allele in Lrig1-expressing progenitor cells results in multiple distal colonic tumors with features of familial adenomatous polyposis.

DIPA-family coiled-coils bind conserved isoform-specific head domain of p120-catenin family: potential roles in hydrocephalus and heterotopia.

Using a new Lrig1 reporter mouse to assess differences between two Lrig1 antibodies in the intestine.

Loss of Lrig1 leads to expansion of Brunner glands followed by duodenal adenomas with gastric metaplasia.

Adenoma-like adenocarcinoma: a subtype of colorectal carcinoma with good prognosis, deceptive appearance on biopsy and frequent KRAS mutation.

LRIG1 Regulates Ontogeny of Smooth Muscle-Derived Subsets of Interstitial Cells of Cajal in Mice.

Linking patient outcome to high throughput protein expression data identifies novel regulators of colorectal adenocarcinoma aggressiveness.

KRAS-dependent sorting of miRNA to exosomes.

Cytometry-based single-cell analysis of intact epithelial signaling reveals MAPK activation divergent from TNF-α-induced apoptosis in vivo.

Ménétrier's Disease: Its Mimickers and Pathogenesis.

KRAS-MEK Signaling Controls Ago2 Sorting into Exosomes.

Identification and characterization of EGF receptor in individual exosomes by fluorescence-activated vesicle sorting.

Micropapillary colorectal carcinoma: clinical, pathological and molecular properties, including evidence of epithelial-mesenchymal transition.

EGF receptor ligands: recent advances.

Impaired coordination between signaling pathways is revealed in human colorectal cancer using single-cell mass cytometry of archival tissue blocks.

Autofluorescence flow sorting of breast cancer cell metabolism.

Circular RNAs are down-regulated in KRAS mutant colon cancer cells and can be transferred to exosomes.

Three-dimensional culture system identifies a new mode of cetuximab resistance and disease-relevant genes in colorectal cancer.

Clustering of integrin α5 at the lateral membrane restores epithelial polarity in invasive colorectal cancer cells.

A Chimeric Egfr Protein Reporter Mouse Reveals Egfr Localization and Trafficking In Vivo.

Optimized multiplex immunofluorescence single-cell analysis reveals tuft cell heterogeneity.

Lrig1+ gastric isthmal progenitor cells restore normal gastric lineage cells during damage recovery in adult mouse stomach.

lncRNA MIR100HG-derived miR-100 and miR-125b mediate cetuximab resistance via Wnt/β-catenin signaling.

p120-Catenin is an obligate haploinsufficient tumor suppressor in intestinal neoplasia.

Unsupervised Trajectory Analysis of Single-Cell RNA-Seq and Imaging Data Reveals Alternative Tuft Cell Origins in the Gut.

Pharmacological blockade of ASCT2-dependent glutamine transport leads to antitumor efficacy in preclinical models.

APC Inhibits Ligand-Independent Wnt Signaling by the Clathrin Endocytic Pathway.

Interpreting heterogeneity in intestinal tuft cell structure and function.

Mutant KRAS Exosomes Alter the Metabolic State of Recipient Colonic Epithelial Cells.

Epithelial Smad4 Deletion Up-Regulates Inflammation and Promotes Inflammation-Associated Cancer.

Diverse Long RNAs Are Differentially Sorted into Extracellular Vesicles Secreted by Colorectal Cancer Cells.

Quantitative assessment of cell population diversity in single-cell landscapes.

Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines.

Blood vessel epicardial substance reduces LRP6 receptor and cytoplasmic β-catenin levels to modulate Wnt signaling and intestinal homeostasis.

Linking ALDH1 and retinoic acid signaling.

Protein kinase A-mediated phosphorylation of naked cuticle homolog 2 stimulates cell-surface delivery of transforming growth factor-α for epidermal growth factor receptor transactivation.

Reassessment of Exosome Composition.

Transfer of Functional Cargo in Exomeres.

Targeted mobilization of Lrig1 gastric epithelial stem cell populations by a carcinogenic type IV secretion system.

miR-302a Inhibits Metastasis and Cetuximab Resistance in Colorectal Cancer by Targeting NFIB and CD44.

Heterogeneity within Stratified Epithelial Stem Cell Populations Maintains the Oral Mucosa in Response to Physiological Stress.

Identification and Characterization of Unique Neutralizing Antibodies to Mouse EGF Receptor.

The Human Tumor Atlas Network: Charting Tumor Transitions across Space and Time at Single-Cell Resolution.

KRAS Mutation-Responsive miR-139-5p inhibits Colorectal Cancer Progression and is repressed by Wnt Signaling.

Combined blockade of EGFR and glutamine metabolism in preclinical models of colorectal cancer.

Succinate Produced by Intestinal Microbes Promotes Specification of Tuft Cells to Suppress Ileal Inflammation.

A smooth muscle-derived, Braf-driven mouse model of gastrointestinal stromal tumor (GIST): evidence for an alternative GIST cell-of-origin.

Clinically adaptable polymer enables simultaneous spatial analysis of colonic tissues and biofilms.

Rab13 regulates sEV secretion in mutant KRAS colorectal cancer cells.

Angiotensin-converting Enzyme 2-containing Small Extracellular Vesicles and Exomeres Bind the Severe Acute Respiratory Syndrome Coronavirus 2 Spike Protein.

Molecular Imaging of Inflammation in Osteoarthritis Using a Water-Soluble Fluorocoxib.

Murine Intrarectal Instillation of Purified Recombinant Toxins Enables Mechanistic Studies of Pathogenesis.

First-in-Human PET Imaging and Estimated Radiation Dosimetry of l-[5-C]-Glutamine in Patients with Metastatic Colorectal Cancer.

Cell surface integrin α5ß1 clustering negatively regulates receptor tyrosine kinase signaling in colorectal cancer cells via glycogen synthase kinase 3.

Translocator protein-targeted photodynamic therapy for direct and abscopal immunogenic cell death in colorectal cancer.

Induction of apically mistrafficked epiregulin disrupts epithelial polarity via aberrant EGFR signaling.

MCMICRO: a scalable, modular image-processing pipeline for multiplexed tissue imaging.

Supermeres are functional extracellular nanoparticles replete with disease biomarkers and therapeutic targets.

Differential pre-malignant programs and microenvironment chart distinct paths to malignancy in human colorectal polyps.

Depletion of METTL3 alters cellular and extracellular levels of miRNAs containing mA consensus sequences.

Quantifying and correcting slide-to-slide variation in multiplexed immunofluorescence images.

MIRIAM: A machine and deep learning single-cell segmentation and quantification pipeline for multi-dimensional tissue images.

Interaction of lncRNA MIR100HG with hnRNPA2B1 facilitates mA-dependent stabilization of TCF7L2 mRNA and colorectal cancer progression.

Significance of a calcium-binding protein S100A14 expression in colon cancer progression.

A CGA/EGFR/GATA2 positive feedback circuit confers chemoresistance in gastric cancer.

Cancer-Associated Fibroblasts and Squamous Epithelial Cells Constitute a Unique Microenvironment in a Mouse Model of Inflammation-Induced Colon Cancer.

Human Colon Cancer-Derived Clostridioides difficile Strains Drive Colonic Tumorigenesis in Mice.

Recent Advances in the Study of Extracellular Vesicles in Colorectal Cancer.

Phase 2 of extracellular RNA communication consortium charts next-generation approaches for extracellular RNA research.

Are Supermeres a Distinct Nanoparticle?

Electrodeposited magnetic nanoporous membrane for high-yield and high-throughput immunocapture of extracellular vesicles and lipoproteins.

Extracellular vesicles and nanoparticles: emerging complexities.

Comprehensive isolation of extracellular vesicles and nanoparticles.

Exosomes, microvesicles, and other extracellular vesicles-a Keystone Symposia report.

Development of Pluoronic nanoparticles of fluorocoxib A for endoscopic fluorescence imaging of colonic adenomas.

exRNA-eCLIP intersection analysis reveals a map of extracellular RNA binding proteins and associated RNAs across major human biofluids and carriers.

Inhibition of the bone morphogenetic protein pathway suppresses tumor growth through downregulation of epidermal growth factor receptor in MEK/ERK-dependent colorectal cancer.

Systematic Assessment of Small RNA Profiling in Human Extracellular Vesicles.

Anapole-Assisted Low-Power Optical Trapping of Nanoscale Extracellular Vesicles and Particles.

GammaGateR: semi-automated marker gating for single-cell multiplexed imaging.

Emerging connections between GPI-anchored proteins and their extracellular carriers in colorectal cancer.

Molecular cartography uncovers evolutionary and microenvironmental dynamics in sporadic colorectal tumors.

Dynamic tuft cell expansion during gastric metaplasia and dysplasia.

Inhibition of autocrine HGF maturation overcomes cetuximab resistance in colorectal cancer.

The Hallmarks of Precancer.

EVPsort: An Atlas of Small ncRNA Profiling and Sorting in Extracellular Vesicles and Particles.

An anion exchange membrane sensor detects EGFR and its activity state in plasma CD63 extracellular vesicles from patients with glioblastoma.

GammaGateR: semi-automated marker gating for single-cell multiplexed imaging.

Extracellular RNA in oncogenesis, metastasis and drug resistance.

Comparison of EV characterization by commercial high-sensitivity flow cytometers and a custom single-molecule flow cytometer.

5-Fluorouracil treatment represses pseudouridine-containing miRNA export into extracellular vesicles.

Consensus tissue domain detection in spatial omics data using multiplex image labeling with regional morphology (MILWRM).

Temporal recording of mammalian development and precancer.

Extracellular vesicles and nanoparticles at a glance.

Integration of lipidomics with targeted, single cell, and spatial transcriptomics defines an unresolved pro-inflammatory state in colon cancer.

Transfer of and increases 3D growth and invasiveness in recipient cancer cells.

Yes-associated protein plays oncogenic roles in human sporadic colorectal adenomas.

Blebbisomes are large, organelle-rich extracellular vesicles with cell-like properties.

Multiomic spatial atlas shows deleted in malignant brain tumors 1 (DMBT1) glycoprotein is lost in colonic dysplasia.

Benchmarking Spatial Co-Localization Methods for Single-Cell Multiplex Imaging Data with Applications to High-Grade Serous Ovarian and Triple Negative Breast Cancer.

Dipeptidase-1-knockout mice develop invasive tumors with features of microsatellite-unstable colorectal cancer.