Universidad Rey Juan Carlos

2 ARTICLES PUBLISHED IN JoVE

Neuroscience

In vivo Positron Emission Tomography to Reveal Activity Patterns Induced by Deep Brain Stimulation in Rats

Marta Casquero-Veiga¹, Nicolás Lamanna-Rama^2,3, Diego Romero-Miguel^2,3, Manuel Desco^1,2,3,4, María Luisa Soto-Montenegro^2,4,5

¹Centro Nacional de Investigaciones Cardiovasculares (CNIC), ²Laboratorio de Imagen Médica, Instituto de Investigación Sanitaria Gregorio Marañón, ³Departamento de Bioingeniería e Ingeniería Aeroespacial, Universidad Carlos III de Madrid, ⁴CIBER de Salud Mental (CIBERSAM), ⁵High Performance Research Group in Physiopathology and Pharmacology of the Digestive System (NeuGut), Universidad Rey Juan Carlos

We describe a preclinical experimental method to evaluate metabolic neuromodulation induced by acute deep brain stimulation with in vivo FDG-PET. This manuscript includes all experimental steps, from stereotaxic surgery to the application of the stimulation treatment and the acquisition, processing, and analysis of PET images.

Neuroscience

Randomized, Triple-Blind, and Parallel-Controlled Trial of Transcranial Direct Current Stimulation for Cognitive Rehabilitation after Stroke

Begoña González Rodríguez^*1,2,3, Elena M. Marrón^*4,5, Marcos Ríos-Lago^1,6,7, Aida Arroyo Ferrer⁸, Yeray González-Zamorano⁹, Francisco José Sánchez Cuesta⁸, David De Noreña¹, Juan Pablo Romero^1,8

¹Brain Damage Unit, Fundación Hospitalarias Madrid, ²International doctoral school, Universidad Nacional de Educación a Distancia (UNED), ³Departamento Posgrado Psicología, Faculty of Biomedical and Health Sciences, Universidad Europea de Madrid, ⁴Faculty of Health Sciences, NeuroADaS Lab, Universitat Oberta de Catalunya, ⁵UNNE Institute of Neuroestimulation, ⁶Faculty of Psychology, Universidad Nacional de Educación a Distancia (UNED), ⁷Department of Neuropsychology, NeuronUP, ⁸Faculty of Experimental Sciences, Universidad Francisco de Vitoria, ⁹Department of Physical Therapy, Occupational Therapy, Rehabilitation, and Physical Medicine, Universidad Rey Juan Carlos

This study presents a novel transcranial direct current stimulation (tDCS) protocol combined with cognitive stimulation to address post-stroke hemispatial neglect. Initial data from a pilot patient ensure the procedure's feasibility and suggest potential efficacy, providing a foundation for a future parallel, triple-blind, controlled clinical trial.