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Chapter 6
When drugs enter the body, they eventually undergo irreversible elimination. Drug elimination primarily involves excretion and metabolism or ...
Eliminating drugs from the body is a vital process that occurs through excretion or metabolism. Understanding the kinetics of drug elimination is crucial ...
The kidneys are primary excretory organs, filtering waste products from the bloodstream and excreting them into urine. The kidneys efficiently eliminate ...
The kidney serves as the primary organ responsible for eliminating drugs and their metabolites from the body. This process, known as renal elimination, ...
After glomerular filtration, substances in the tubular lumen transport back into the bloodstream via tubular reabsorption. Nutrients are actively ...
Blood exits glomeruli via efferent arterioles, reaching the capillary plexus surrounding the proximal tubule. Here, unfiltered drugs are secreted into the ...
Urine pH and a drug's pKa determine its percentage ionization, which influences renal reabsorption and elimination. Urine pH depends on diet, drug ...
The hepatic biliary system expels drugs and metabolites via bile secretions. Hepatocytes lining bile canaliculi produce bile that contains water, ...
Bile, produced by hepatocytes, primarily comprises water, bile salts, and pigments. Membrane transporters in hepatocytes transfer the drug into bile. ...
Drugs are excreted through various unconventional routes, including the lungs, breast milk, and saliva. In the lungs, volatile drugs diffuse into the ...
Various bodily processes, including sweating, tears, and the digestive system, contribute to drug excretion. Nonionized lipophilic drugs passively diffuse ...
A drug that enters the body gets eliminated by the kidneys and liver through urine or bile, respectively. A pharmacokinetic parameter, drug clearance, ...
Drug clearance features irreversible drug removal from any organ in the body. Physiological models determine clearance through an individual organ, ...
Clearance directly measures drug elimination from the central compartment, which comprises plasma and highly perfused organs like kidneys and liver. ...
Typically, clearance describes the drug elimination from the body using compartment models. An alternative, the noncompartmental approach, estimates ...
Renal clearance is defined as a constant fraction of the central volume of distribution containing the drug excreted by the kidney per unit of time. It is ...
Renal clearance is the summation of kidney filtration, secretion, and reabsorption calculated by a specific equation. It is typically associated with the ...
Various factors impact a drug's renal clearance, including its physical-chemical properties and plasma levels. Molecular size, lipid solubility, and ...
Renal clearance, pivotal in drug elimination, can be affected by drug distribution and interactions. Drugs with a large distribution volume or bound to ...
Renal dysfunction significantly impairs renal drug clearance. Renal failure can be caused by various factors. Uremia, characterized by impaired glomerular ...
In patients with renal impairment, drugs exhibit altered pharmacokinetics. Reduced renal clearance and elimination rate result in prolonged elimination ...
Renal clearance can be determined using graphical and midpoint methods. In the graphical method, clearance can be calculated and obtained by plotting the ...
Hepatic clearance is the volume of blood cleared of a drug by the liver per unit of time. It equals total body clearance minus renal clearance. Most ...
Hepatic clearance can be affected by protein binding based on the extraction ratio of the drug. Drugs with high extraction ratios are flow-limited and ...
In the liver's bile canaliculi, modification of influx and efflux transporters can influence intrinsic clearance. Transporters play a major role in ...
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