Chapter 6
Principles of Mass Spectrometry
Spettrometria di massa: panoramica
Mass spectrometry is an analytical technique used to determine the molecular mass and molecular formula of a compound. The basic principle of mass ...
Spettrometria di massa: effetto isotopico
Most elements exist in nature as a mixture of isotopes. The isotopes differ in weight due to their respective number of neutrons. The molecular weight of ...
Spettrometria di massa: Panoramica sulla frammentazione molecolare
The ionization of a molecule into a molecular ion inside the mass spectrometer causes instability in the molecule's structure due to the loss of an ...
Spettrometri di massa
This lesson details the instrumentation of a mass spectrometer—a physical instrument to perform mass spectrometry on analyte molecules and record ...
Spettro di massa
A mass spectrum is the graphical representation of the relative abundance of the charged fragments in an analyte plotted against their mass-to-charge ...
Spettro di massa: interpretazione
Given a known molecular ion mass, the unknown compound can be identified.
The empirical formula is determined from the molecular ion mass and the isotope ...
Analizzatori di massa: Panoramica
Common mass analyzers include magnetic sector, double-focusing, quadrupole, time-of-flight, and ion trap analyzers.
The capability of any mass analyzer ...
Analizzatori di massa: tipi comuni
The quadrupole mass analyzer consists of four parallel rods, across which are applied a DC voltage and a radio-frequency AC voltage.
Here, the field ...
Spettrometria di massa ad alta risoluzione (HRMS)
The resolution of a mass spectrometer depends on the efficiency of separating ions with different ion masses. The mass of an atom is approximated to the ...
Spettrometria di massa: analisi complessa
The analysis of complex mixtures requires the combination of separation methods and mass spectrometry in sequence, termed hyphenated methods.
GC–MS ...
Spettrometria di massa tandem
Tandem mass spectrometry, or MS/MS, combines two mass analyzers in sequence, connected by a collision or interaction cell.
First, the samples are ionized ...
Gascromatografia-Spettrometria di massa (GC-MS)
Gas chromatography–mass spectrometry (GC–MS) is the combination of analytical techniques of gas chromatography and mass spectrometry in a ...
Spettrometria di massa al plasma accoppiato induttivamente (ICP-MS): Panoramica
Inductively coupled plasma–mass spectrometry, or ICP–MS, uses an ICP source to prepare samples for atomic mass spectrometry.
Solution-state ...
Spettrometria di massa al plasma accoppiato induttivamente (ICP-MS): Interferenze
Despite the advantages offered by ICP–MS, accurate elemental analysis is affected by spectroscopic and non-spectroscopic interferences.
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