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7.13 : Two-Compartment Open Model: IV Bolus Administration

The two-compartment model for intravenous (IV) bolus administration illustrates drug distribution in the body, subdividing it into central and peripheral compartments. This model operates on the concept of two-compartment kinetics. The drug's plasma concentration shows a bi-exponential decline following IV bolus administration, signaling the presence of two disposition processes: distribution and elimination.

The disparity between drug input and the sum of drug transfer rates between compartments and elimination determines the rate of change in drug concentration. The transfer constants k12 and k21 depict the rate at which the drug moves between these compartments.

The method of residuals is employed to estimate these transfer constants and other pharmacokinetic parameters. In this method, the slope of the residual line provides the elimination rate constant (k). From k, we can calculate the elimination half-life (t1/2). Other essential pharmacokinetic parameters like the volume of distribution (Vd) and clearance (Cl) can also be determined using suitable equations. All these parameters help in understanding the behavior of the drug within the body.

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Two Compartment ModelIV Bolus AdministrationDrug DistributionCentral CompartmentPeripheral CompartmentTwo compartment KineticsPlasma ConcentrationBi exponential DeclineDistribution ProcessElimination ProcessTransfer ConstantsK12K21Method Of ResidualsElimination Rate ConstantElimination Half lifeVolume Of DistributionClearancePharmacokinetic Parameters

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7.13 : Two-Compartment Open Model: IV Bolus Administration

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7.1 : Analysis Methods of Pharmacokinetic Data: Model and Model-Independent Approaches

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7.2 : Model Approaches for Pharmacokinetic Data: Compartment Models

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7.3 : One-Compartment Open Model for IV Bolus Administration: General Considerations

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7.4 : One-Compartment Open Model for IV Bolus Administration: Estimation of Elimination Rate Constant, Half-Life and Volume of Distribution

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7.5 : One-Compartment Open Model for IV Bolus Administration: Estimation of Clearance

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7.6 : One-Compartment Model: IV Infusion

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7.7 : One-Compartment Open Model for Extravascular Administration: Zero-Order Absorption Model

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7.8 : One-Compartment Open Model for Extravascular Administration: First-Order Absorption Model

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7.9 : One-Compartment Open Model: Wagner-Nelson and Loo Riegelman Method for ka Estimation

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7.10 : One-Compartment Open Model: Urinary Excretion Data and Determination of k

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7.11 : Multicompartment Models: Overview

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7.12 : Two-Compartment Open Model: Overview

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7.14 : Two-Compartment Open Model: IV Infusion

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7.15 : Two-Compartment Open Model: Extravascular Administration

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