Chapter 4
Pharmacokinetics: Drug Distribution and Protein Binding
Arzneimittelverteilung: Überblick
Distribution refers to the two-way movement of a drug between different compartments within the body.
It is a passive process driven by the concentration ...
Faktoren, die die Wirkstoffverteilung beeinflussen: Gewebepermeabilität
Drug distribution across biological membranes to target tissues relies on the drug's physicochemical properties, such as molecular size, ionization ...
Faktoren, die die Arzneimittelverteilung beeinflussen: Physiologische Barrieren
Drug distribution is governed by several physiological barriers.
The simple capillary endothelial barrier limits the passage of drugs larger than 600 ...
Faktoren, die die Verteilung von Medikamenten beeinflussen: Organperfusionsrate
Drug distribution can be perfusion rate-limited, particularly when the drug is highly lipophilic, and the membrane to cross is highly permeable.
The ...
Faktoren, die die Arzneimittelverteilung beeinflussen: Verschiedene Faktoren
Drug distribution can be affected by various factors.
It can vary with age due to differences in body composition. For instance, older adults have less ...
Verteilungsvolumen
The apparent volume of distribution or Vd is a key pharmacokinetic parameter signifying the hypothetical body fluid volume into which a drug disperses.
It ...
Protein-Wirkstoff-Bindung: Mechanismus und Kinetik
Protein-drug binding is the interaction between drugs and proteins in the body.
It can be either intracellular binding, which involves drug interactions ...
Bindung von Arzneimitteln an Blutbestandteile
When drugs enter the systemic circulation, they interact with blood components like human serum albumin or HSA, α1-acid glycoprotein or AAG, ...
Gewebe-Wirkstoff-Bindung: Lokalisierung von Wirkstoffen und ihre Bedeutung
Body tissues comprise 40-90% of body weight depending on body composition. They can serve as drug storage sites, competing with plasma binding sites.
...
Protein-Wirkstoff-Bindung: Bestimmungsmethoden
Protein-drug binding is determined through indirect and direct methods.
Indirect methods involve isolating the bound drug from its free form in biological ...
Faktoren, die die Protein-Wirkstoff-Bindung beeinflussen: Arzneimittelbezogene Faktoren
Protein-drug binding can be affected by various drug-related factors.
The degree of protein binding is closely related to a drug's lipophilicity, with ...
Faktoren, die die Protein-Wirkstoff-Bindung beeinflussen: Proteinbezogene Faktoren
Drug binding to proteins depends on various factors, including physicochemical properties, protein concentration, disease states, and the number of ...
Faktoren, die die Protein-Wirkstoff-Bindung beeinflussen: Wechselwirkungen mit anderen Medikamenten
Drug displacement interactions arise when drugs compete for the same binding site, leading to displacement.
The extent of displacement depends on the ...
Faktoren, die die Protein-Wirkstoff-Bindung beeinflussen: patientenbezogene Faktoren
Protein-drug binding varies with many patient-related factors.
Age impacts binding due to varying protein content in different age groups. Neonates ...
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