Kapitel 40
Ein hierarchisches Stammzellsystem: Bildung von Blutzellen
Überblick über das Gefäßsystem
The vascular system comprises an extensive network of arteries, capillaries, and veins. The vascular system can be broadly divided into the blood and ...
Mechanismus der Angiogenese
Blood vessel formation starts early during embryonic development, around day 7. In the extraembryonic yolk sac, mesodermal precursor cells called ...
Regulierung von Angiogenese und Blutversorgung
Rapidly dividing tumors, embryos, and wounded tissues require more oxygen than usual, lowering the oxygen concentration in the blood. At low oxygen or ...
Hämatopoese
The process of blood cell formation is called hematopoiesis. Hematopoiesis starts early during development, on the seventh day of embryogenesis. This ...
Multipotenz von hämatopoetischen Stammzellen
The hematopoietic stem cells or HSCs are multipotent, meaning they can differentiate and give rise to all blood and immune cells. HSCs are maintained in ...
Festlegung der Zelllinie
Commitment is the process whereby stem cells:
lose their ability to form all cell types and
irreversibly change into a specific type.
The ...
Erythropoese
Red blood cells (RBCs) transport oxygen to all body tissues. These cells survive only for 120 days and then need to be replenished. Erythropoiesis ...
Differenzierung gewöhnlicher myeloischer Progenitorzellen
Common myeloid progenitors (CMPs) are oligopotent cells that can differentiate into granulocytes and macrophages. Granulocytes and macrophages are ...
Regulierung von hämatopoetischen Stammzellen
All blood and immune cells are produced from the multipotent hematopoietic stem cells (HSCs) by the process of hematopoiesis. However, they all have a ...
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