Drug elimination refers to drug removal from the body, either through urine or bile, by the kidneys or liver, respectively. A pharmacokinetic parameter, drug clearance, measures the efficiency of drug removal from the bloodstream within a specific time frame. It is calculated as the rate at which a drug is eliminated from plasma divided by the drug's concentration in plasma.
Drug clearance is not limited to renal excretion but encompasses all organs involved in drug elimination, including the liver, lungs, and biliary system. The sum of clearances by all eliminating organs is known as the total body or systemic clearance. It can be expressed as a combination of renal clearance and nonrenal clearance.
Understanding drug elimination kinetics and the concept of drug clearance is essential for designing effective dosage regimens and ensuring safe and optimal drug therapy. It allows for individualized adjustments based on a person's specific needs.
Exceeding the prescribed dosing rate can overload elimination pathways and decrease drug clearance. This leads to elevated plasma drug concentrations, which can result in toxic levels and cause adverse effects.
来自章节 6:
Now Playing
Pharmacokinetics: Drug Excretion and Clearance
57 Views
Pharmacokinetics: Drug Excretion and Clearance
1.1K Views
Pharmacokinetics: Drug Excretion and Clearance
485 Views
Pharmacokinetics: Drug Excretion and Clearance
125 Views
Pharmacokinetics: Drug Excretion and Clearance
180 Views
Pharmacokinetics: Drug Excretion and Clearance
115 Views
Pharmacokinetics: Drug Excretion and Clearance
144 Views
Pharmacokinetics: Drug Excretion and Clearance
140 Views
Pharmacokinetics: Drug Excretion and Clearance
1.1K Views
Pharmacokinetics: Drug Excretion and Clearance
94 Views
Pharmacokinetics: Drug Excretion and Clearance
85 Views
Pharmacokinetics: Drug Excretion and Clearance
48 Views
Pharmacokinetics: Drug Excretion and Clearance
52 Views
Pharmacokinetics: Drug Excretion and Clearance
53 Views
Pharmacokinetics: Drug Excretion and Clearance
44 Views
See More
版权所属 © 2025 MyJoVE 公司版权所有,本公司不涉及任何医疗业务和医疗服务。