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7.24 : Model Approaches for Pharmacokinetic Data: Distributed Parameter Models

Pharmacokinetic models are mathematical constructs that represent and predict the time course of drug concentrations in the body, providing meaningful pharmacokinetic parameters. These models are categorized into compartment, physiological, and distributed parameter models.

The distributed parameter models are specifically designed to account for variations and differences in some drug classes. This model is particularly useful for assessing regional concentrations of anticancer or cardiovascular medications that target specific tumors and specific areas of the heart, respectively. However, the exhaustive data collection is challenging, and the mathematical equations are quite complex.

Tags

Pharmacokinetic ModelsDistributed Parameter ModelsCompartment ModelsPhysiological ModelsDrug ConcentrationsPharmacokinetic ParametersRegional ConcentrationsAnticancer MedicationsCardiovascular MedicationsMathematical EquationsData Collection Challenges

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7.24 : Model Approaches for Pharmacokinetic Data: Distributed Parameter Models

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7.1 : Analysis Methods of Pharmacokinetic Data: Model and Model-Independent Approaches

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7.2 : Model Approaches for Pharmacokinetic Data: Compartment Models

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7.3 : One-Compartment Open Model for IV Bolus Administration: General Considerations

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7.4 : One-Compartment Open Model for IV Bolus Administration: Estimation of Elimination Rate Constant, Half-Life and Volume of Distribution

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7.5 : One-Compartment Open Model for IV Bolus Administration: Estimation of Clearance

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7.6 : One-Compartment Model: IV Infusion

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7.7 : One-Compartment Open Model for Extravascular Administration: Zero-Order Absorption Model

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7.8 : One-Compartment Open Model for Extravascular Administration: First-Order Absorption Model

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7.9 : One-Compartment Open Model: Wagner-Nelson and Loo Riegelman Method for ka Estimation

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7.10 : One-Compartment Open Model: Urinary Excretion Data and Determination of k

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7.11 : Multicompartment Models: Overview

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7.12 : Two-Compartment Open Model: Overview

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7.13 : Two-Compartment Open Model: IV Bolus Administration

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7.14 : Two-Compartment Open Model: IV Infusion

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