Pharmacokinetic models are mathematical constructs that represent and predict the time course of drug concentrations in the body, providing meaningful pharmacokinetic parameters. These models are categorized into compartment, physiological, and distributed parameter models.
The distributed parameter models are specifically designed to account for variations and differences in some drug classes. This model is particularly useful for assessing regional concentrations of anticancer or cardiovascular medications that target specific tumors and specific areas of the heart, respectively. However, the exhaustive data collection is challenging, and the mathematical equations are quite complex.
From Chapter 7:
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