Creation of a Knee Joint-on-a-Chip for Modeling Joint Diseases and Testing Drugs
3.6K Views
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12:44 min
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January 27th, 2023
DOI :
January 27th, 2023
•Meagan J. Makarcyzk1,2, Zhong Alan Li1,3, Ilhan Yu1, Haruyo Yagi1, Xiurui Zhang1, Lauren Yocum1, Eileen Li1, Madalyn R. Fritch1, Qi Gao4, Bruce A. Bunnell5, Stuart B. Goodman4,6, Rocky S. Tuan1,8, Peter G. Alexander1,7, Hang Lin1,2,7
1Department of Orthopaedic Surgery, University of Pittsburgh School of Medicine, 2Department of Bioengineering, University of Pittsburgh Swanson School of Engineering, 3Department of Neurobiology, University of Pittsburgh School of Medicine, 4Department of Orthopaedic Surgery, Stanford University, 5Department of Microbiology, Immunology, and Genetics, University of North Texas Health Science Center, 6Department of Bioengineering, Stanford University, 7McGowan Institute for Regenerative Medicine, University of Pittsburgh School of Medicine, 8The Chinese University of Hong Kong
Chapters in this video
0:05
Introduction
0:43
Engineering the Tissue Components
5:49
Establishing the Minijoint Chip
8:13
Individual Tissue Collection
9:35
Results: Establishment of a Miniature Synovial Joint-Mimicking Microphysiological System
12:07
Conclusion
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