Enhancing the Engraftment of Human Induced Pluripotent Stem Cell-derived Cardiomyocytes via a Transient Inhibition of Rho Kinase Activity
6.1K Views
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08:00 min
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July 10th, 2019
DOI :
July 10th, 2019
•Meng Zhao1, Yawen Tang1, Patrick J. Ernst1,2, Asher Kahn-Krell1, Chengming Fan1,3, Danielle Pretorius1, Hanxi Zhu1, Xi Lou1, Lufang Zhou2, Jianyi Zhang1, Wuqiang Zhu1
1Department of Biomedical Engineering, School of Medicine, School of Engineering, University of Alabama at Birmingham, 2Division of Cardiovascular Diseases, School of Medicine, School of Engineering, University of Alabama at Birmingham, 3Department of Cardiac Surgery, The Second Xiangya Hospital of Central South University
Chapters in this video
0:04
Title
1:13
hiPSC-CMs Purification, Small Molecule Pre-treatment, Myocardial Infarction, and Cell Transplantation
3:42
Calcium Transient and Contractility Recording
5:21
Results: Increased Engraftment of Transplanted hiPSC-CM Preconditioned with the ROCK Inhibitor Y-27632 in a Murine MI Model
7:11
Conclusion
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