Standardized Histomorphometric Evaluation of Osteoarthritis in a Surgical Mouse Model
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11.9K Views
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07:32 min
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May 6th, 2020
DOI :
May 6th, 2020
•William J. Pinamont1, Natalie K. Yoshioka1, Gregory M. Young1, Vengadeshprabhu Karuppagounder1, Elijah L. Carlson1, Adeel Ahmad1, Reyad Elbarbary1,2, Fadia Kamal1,3
1Center for Orthopedic Research and Translational Sciences, Department of Orthopedics and Rehabilitation, Pennsylvania State College of Medicine, 2Department of Biochemistry and Molecular Biology, Pennsylvania State College of Medicine, 3Department of Pharmacology, Pennsylvania State College of Medicine
Rozdziały w tym wideo
0:04
Introduction
1:13
Histomorphometric Analysis Setup
1:59
Total, Calcified, and Uncalcified Cartilage Area Measurements
2:47
Chondrocyte Number and Phenotype Evaluation
3:17
Tibial Articular Surface Perimeter Measurement
3:47
Subchondral Bone and Marrow Space Area Measurement
4:30
Anterior and Posterior Osteophyte Area and Synovial Thickness Measurement
5:21
Results: Representative Histomorphometric Osteoarthritis (OA) Evaluation in Destabilization of the Medial Meniscus (DMM) and Sham Mice
7:06
Conclusion
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