著者は私たちの紙とウォルター ・螺子 (研究科神経生理学、生物医学センター、医療技術の重要な見直しのキャロライン ・ ハートリーと位スレーター (小児科部、オックスフォード大学、イギリス) を認識したいです。マンハイム (CBTM)、ハイデルベルク大学、ドイツ) 技術的な機器や知識を私たちをサポートするため。

研究は、有能な倫理委員会の北西スイス連邦共和国 (EKNZ 2015-079) によって承認された、測定の前に参加者の通知書面による保護者の同意を得た。
1. 準備
<ol><li>赤ちゃんが解決されていることを確認します。それは動きの人工物のため録画中に動を吸うことがなく静かで落ち着いたをする必要があります。赤ちゃんは、眠っている9をすることができます。</li>
	<li>脳波キャップのサイズを定義する測定テープと新生児の頭囲を測定します。</li>
	<li>アクティブ電極の位置を識別する: Cz/皮膚マーカー鉛筆でナジオンとイオンと左右の preaurical の間の中間点の間の中間ポイントをマークすることによって頂点の位置がポイントします。位置決め用電極はまた図 1参照してください。</li>
	<li>接地電極の位置を識別する: 右額 (フリー走行 2) と参照電極: 左乳様突起 (A1)。</li>
	<li>綿棒を使用して消毒剤できれいに電極 (Cz、フリー走行 2、A1)。髪の多くの場合頭皮を視覚化する髪を区切ります。</li>
	<li>ペーストを準備中、インピー ダンスを下げるため、綿棒を使用して脳波電極サイトをやさしくスクラブします。</li>
	<li>新生児の頭に取り付けられた電極脳波キャップを置きます。</li>
	<li>短いプラスチック製の針と注射器を使用して電極と頭皮の接触を最適化する電極に導電性の脳波ゲルを注入します。</li>
	<li>製造元の推奨事項や公開されているガイドライン12で説明されるように、インピー ダンスが 50 kΩ を下回るまで電極を調整します。</li>
	<li>新生児の表情を記録するためのカメラを位置します。</li>
	<li>脳波記録装置に固定されている連絡先トリガー デバイスにフラット チップ型プローブを接続します。フラット チップ型プローブには、皮膚に公称力が達すると、連絡先トリガー デバイスでトリガー信号が生成されます。この信号は、トリガー マークと脳波をタグ付け、コンピューターに送信されます。</li>
</ol>2. 測定
<ol><li>データを格納する試験名を選択します。</li>
	<li>
オンライン帯域通過フィルターを追加します。
	<ol>
<li>フィルターを表示します。 低カットオフ フィルター: 周波数: 1 Hz 高カットオフ フィルター: 周波数: 70 Hz ノッチ フィルター: 50 Hz サンプリング レート: 2000 Hz</li>
	</ol>
</li>
	<li>脳波とビデオ録画を開始します。</li>
	<li>水平位置に新生児の右手を保持します。刺激は、別のサイトにも適用できるなどの手からよりも長い待ち時間になります、足を参照してください詳細については 3.7。</li>
	<li>最初の脳波を記録します。新生児の手を開催しながら手動で刺激が適用されていない幼児は休憩期間を記録する脳波記録に注釈を付けます。</li>
	<li>新生児の右手に研究設計に従ってフラット先端プローブ刺激の量を行います。私たちの実験的なデザインで設定、50 フラット先端プローブ刺激の数。先端が曲げていない、正しい力が適用されますので、フラット先端プローブを垂直に新生児の手を使用するように注意します。総和を避けるために 2 を 3 の刺激間間隔 (ISI)6の最小値を使用してフラット先端プローブ刺激を実行します。</li>
	<li>すべての録音を停止します。</li>
	<li>実験的設定の詳細を文書化します。</li>
</ol>3. データ分析
<ol><li>1 Hz と 30 Hz でローパス フィルター、ハイパス フィルターを使用してオフライン生脳波データをフィルターします。</li>
	<li>1,500 ms (刺激発症後 1,000 ms 前に 500 ms) の新紀元でデータを分割します。</li>
	<li>前刺激間隔にベースライン補正を実行します。</li>
	<li>目視検査後動きの工芸品、ノイズの低減など、工芸品を含む脳波新紀元を手動で拒否します。またチュートリアルの概要を参照してください: https://sccn.ucsd.edu/wiki/Chapter_01:_Rejecting_Artifacts</li>
	<li>脳波の新紀元の平均 (背景と刺激応答のため別途)。</li>
	<li>木質フィルター最大ジッタ ± 期間 0 - 1,000 ms で 50 ms のデータは投稿刺激発症です。これにより、乳児の待機時間の違い。これは別に背景と刺激応答に対して行います。</li>
	<li>独立したデータセットで定義されたに記載されている有害な誘発脳波のテンプレートをプロジェクトそれぞれの個々 の試験内で有害な誘発応答の大きさを確認するためにデータに11の詳細他の場所。テンプレートは有害誘発応答の特徴的な波形を表し、大きさは個々 の裁判でこの有害誘発応答の量を反映します。 注: テンプレートをプロジェクトする時間ウィンドウは幼児と刺激提示位置の年齢に依存しています。興味の時間帯が手に刺激が適用されます 200-500 ms は刺激11を掲載します。興味の時間帯は、足に刺激が適用されます 400 700 ms は刺激11を掲載します。このテンプレートは、34-43 週の妊娠の間の幼児のためだけ現在検証されていることに注意してください。このテンプレート、および制限の議論を使用してに関連付けられた詳細なメソッド、ハートリーら201711を参照してください。</li>
	<li>テンプレートを使用しては背景脳波に比べて刺激が以下より有意に高く有害誘発脳波の大きさが計算されることを確認します。</li>
	<li>その後行動の顔表情の分析 (カメラ、脳波にリンクされて記録) 新生児の顔のコーディング システム2,13を使用して。</li>
</ol>

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著者が明らかに何もありません。

ここで紹介した方法は、どのように有害な誘発脳を示しています新生児の活動は脳波記録とフラット チップ型プローブを刺激する薬を使用して実験的侵害刺激を適用する客観的な方法で測定できます。この手法は、侵害受容、例えば新生児など非言語的者を検出する様々 な臨床設定で使用できます。完全な研究は、赤ちゃんを識別する、準備し電極を取り付け、最後に適用と記録 50 ?...

痛みは、実際または潜在的な組織損傷に関連付けられているまたはそのような損傷の1の点で説明されている不愉快な感覚的で、感情的な経験です。口頭で伝えることができない個人は、痛みが発生しているが、新生児2の例のための疼痛緩和治療を評価するために非常に困難になります可能性を否定しません。いくつかの行動および生理学的指標は、非言語の患者さんの痛みを評価するために使用されます。さまざまなスケールは、長年にわたって開発されている、刺激、妊娠年齢、新生児に埋め込まれた3,4,5環境の種類によって決まります。これらの痛みの評価ツールは、評価者の解釈に依存するかまたはセカンダリの生理学的指標を要求します。
このビデオでは新生児での使用に最適化された電気生理学的記録と侵害受容を評価する手法を提案します。侵害受容は、侵害刺激をエンコーディングの神経プロセスとして定義されます。したがって、侵害受容を量的に表わすは非言語的直々 の神経入力を決定するエレガントな方法です。さらに、皮質活動の脳波 (EEG) によって検出された有害イベント5,6の強さと相関しています。
ここで紹介した方法は、針を刺した7、皮膚破壊ではない、行動遭難6は発生しませんとも呼ばれるフラット先端プローブを用いた機械的刺激によって生成される有害刺激と脳波記録を兼ね備えています。主には皮膚の病変8と侵害受容性固有の大きさを潜在的な破壊に依存しない必要がない Aδ 繊維によって媒介される刺激を侵害受容の次に強調、それは示されている睡眠状態9。両親は新生児と研究の設定でこのメソッドを適用するときに、プローブにもに受け付けています。プローブは、プローブ接触皮膚とき正確にタグ付けする脳波記録を有効にする脳波記録システムに電子的にリンクされます。これは大幅に時間ロックのプロセスを簡素化し、以降すべての脳波解析の前提です。幼児の脳波記録の準備時間を最小限にするために 3 つの電極 (図 1) の最低限の要件に電極の数を減らしました変更された国際 10/20 電極配置システムを使用しました。有害な誘発脳活動は最大9,10、11、中央頂点 Cz 電極は、1 つの参照および 1 つの接地電極を併用しました。

<table><tbody><tr><td>Easycap</td><td>EASYCAP GmbH</td><td>AC-32-C</td><td>EEG caps for infants sizes 34 and 36</td></tr><tr><td>actiCAP</td><td>Brain Products GmbH</td><td>BP-04243-SIG</td><td>active electrodes</td></tr><tr><td>ImpBox</td><td>Brain Products GmbH</td><td></td><td>impedance measurement</td></tr><tr><td>V-Amp</td><td>Brain Products GmbH</td><td></td><td>EEG recording device</td></tr><tr><td>Contact trigger for pinprick stimulation</td><td>MRC Systems GmbH</td><td></td><td></td></tr><tr><td>PinPrick stimulator set</td><td>MRC Systems GmbH</td><td></td><td></td></tr><tr><td>EEG prepping paste</td><td>USB Pharmacy</td><td></td><td>contains sodium chloride, pumice stone, propylene glycol</td></tr><tr><td>SuperVisc</td><td>EASYCAP GmbH</td><td></td><td>Electrolyte-Gel for active electrodes</td></tr><tr><td>Brain Vision Recorder</td><td>Brain Products GmbH</td><td></td><td></td></tr><tr><td>Brain Vision Analyzer</td><td>Brain Products GmbH</td><td></td><td></td></tr><tr><td>MATLAB using EEGLAB &lt;p&gt;&lt;/p&gt; &lt;p&gt;&lt;/p&gt; &lt;p&gt;&lt;/p&gt; &lt;p&gt;&lt;/p&gt; &lt;p&gt;&lt;/p&gt; </td><td>Swartz Center for Computational Neuroscience, University of California San Diego</td><td></td><td>For EEG processing, including averaging of all EEG epochs &lt;p&gt;&lt;/p&gt; &lt;p&gt;&lt;/p&gt; &lt;p&gt;&lt;/p&gt; </td></tr></tbody></table>

electrophysiological measurement of noxious-evoked brain activity in neonates using a flat-tip probe coupled to electroencephalography

痛みは、不愉快な感覚的で、感情的な経験です。非言語的患者における痛みの評価ツールでも、痛みを測定する非常に困難です。これらのツールは、主観的または鎮痛の効果を探るときに特にも特定の制限を持っている二次の生理学的指標を決定します。皮質の処理は痛みの知覚に不可欠な脳活動対策、幼児の痛みを評価するために有用なアプローチを提供します。新生児の使用のために最適化された電気生理学的脳活動記録と侵害受容を評価する方法をご紹介します。標準化された性の再現性, 刺激を生成するには、フラット先端プローブ、例えば、針を刺した、皮膚破壊ではない、行動の苦痛を引き起こさないと機械的刺激を適用しました。有害誘発電位は、非言語的患者における侵害受容の客観的測定を可能します。このメソッドは、妊娠 34 週には早くも新生児で使用できます。さらに、鎮痛剤や麻酔薬の有効性の測定などさまざまな状況で適用でした。

図 1は、修正された国際 10/20 電極配置システムを用いた位置決め制御電極の図式です。図 2は、直前とプローブを用いたフラット チップ 32 mN の力で刺激が発生しました (図 2 a) 新生児の右手にプロトコルの説明に従って 1 つの単一侵害刺激の適用後を記録された脳波の活動を示しています。有害な誘?...

Watch this Scientific Journal Video about Electrophysiological Measurement of Noxious-evoked Brain Activity in Neonates Using a Flat-tip Probe Coupled to Electroencephalography at JoVE.com

Electrophysiological Measurement of Noxious-evoked Brain Activity in Neonates Using a Flat-tip Probe Coupled to Electroencephalography

新生児脳波に結合されたフラット先端プローブを用いた有害誘発脳活動の電気生理学的測定

非言語的患者の痛みの測定は困難です。本研究では客観的に有害な誘発脳波を検出するフラット先端プローブを用いた刺激における脳波計測記録と組み合わせています。

Pain is an unpleasant sensory and emotional experience. In non-verbal patients, it is very difficult to measure pain, even with pain assessment tools. ...

electrophysiological-measurement-noxious-evoked-brain-activity

Universidad de Cartagena UDEC

Research

JoVE Journal

Medicine

6.5K ビュー.  University of Basel Children's Hospital. 非言語的患者の痛みの測定は困難です。本研究では客観的に有害な誘発脳波を検出するフラット先端プローブを用いた刺激における脳波計測記録と組み合わせています。

ビデオ: Electrophysiological Measurement of Noxious-evoked Brain Activity in Neonates Using a Flat-tip Probe Coupled to Electroencephalography

Infant Auditory Processing and Event-related Brain Oscillations

Rapid auditory processing and acoustic change detection abilities play a critical role in allowing human infants to efficiently process the fine spectral and temporal changes that are characteristic of human language. These abilities lay the foundation for effective language acquisition; allowing infants to hone in on the sounds of their native language. Invasive procedures in animals and scalp-recorded potentials from human adults suggest that simultaneous, rhythmic activity (oscillations) between and within brain regions are fundamental to sensory development; determining the resolution with which incoming stimuli are parsed. At this time, little is known about oscillatory dynamics in human infant development. However, animal neurophysiology and adult EEG data provide the basis for a strong hypothesis that rapid auditory processing in infants is mediated by oscillatory synchrony in discrete frequency bands. In order to investigate this, 128-channel, high-density EEG responses of 4-month old infants to frequency change in tone pairs, presented in two rate conditions (Rapid: 70 msec ISI and Control: 300 msec ISI) were examined. To determine the frequency band and magnitude of activity, auditory evoked response averages were first co-registered with age-appropriate brain templates. Next, the principal components of the response were identified and localized using a two-dipole model of brain activity. Single-trial analysis of oscillatory power showed a robust index of frequency change processing in bursts of Theta band (3 - 8 Hz) activity in both right and left auditory cortices, with left activation more prominent in the Rapid condition. These methods have produced data that are not only some of the first reported evoked oscillations analyses in infants, but are also, importantly, the product of a well-established method of recording and analyzing clean, meticulously collected, infant EEG and ERPs. In this article, we describe our method for infant EEG net application, recording, dynamic brain response analysis, and representative results.

High-density electroencephalography (dEEG) is being used increasingly to study brain development and plasticity in the early years of life. Here we present an application of sophisticated analysis techniques that builds on traditional EEG recording to understand the oscillatory dynamics of rapid auditory processing in the infant brain.

幼児聴覚処理とイベント関連の脳の振動

Rapid auditory processing and acoustic change detection abilities play a critical role in allowing human infants to efficiently process the fine spectral ...

行動学

Electrophysiological Measurements and Analysis of Nociception in Human Infants

Pain is an unpleasant sensory and emotional experience. Since infants cannot verbally report their experiences, current methods of pain assessment are based on behavioural and physiological body reactions, such as crying, body movements or changes in facial expression. While these measures demonstrate that infants mount a response following noxious stimulation, they are limited: they are based on activation of subcortical somatic and autonomic motor pathways that may not be reliably linked to central sensory processing in the brain. Knowledge of how the central nervous system responds to noxious events could provide an insight to how nociceptive information and pain is processed in newborns.
The heel lancing procedure used to extract blood from hospitalised infants offers a unique opportunity to study pain in infancy. In this video we describe how electroencephalography (EEG) and electromyography (EMG) time-locked to this procedure can be used to investigate nociceptive activity in the brain and spinal cord.
This integrative approach to the measurement of infant pain has the potential to pave the way for an effective and sensitive clinical measurement tool.

The assessment and treatment of pain in infants is difficult because infants cannot verbally report their experience. In this video we describe quantitative electrophysiological methods and analysis techniques that can be used to measure the response to noxious events from the infant nervous system.

電気生理学的測定とヒト幼児における痛覚の分析

Pain is an unpleasant sensory and emotional experience. Since infants cannot verbally report their experiences, current methods of pain assessment are ...

神経科学

Preterm EEG: A Multimodal Neurophysiological Protocol

Since its introduction in early 1950s, electroencephalography (EEG) has been widely used in the neonatal intensive care units (NICU) for assessment and monitoring of brain function in preterm and term babies. Most common indications are the diagnosis of epileptic seizures, assessment of brain maturity, and recovery from hypoxic-ischemic events. EEG recording techniques and the understanding of neonatal EEG signals have dramatically improved, but these advances have been slow to penetrate through the clinical traditions. The aim of this presentation is to bring theory and practice of advanced EEG recording available for neonatal units. 
In the theoretical part, we will present animations to illustrate how a preterm brain gives rise to spontaneous and evoked EEG activities, both of which are unique to this developmental phase, as well as crucial for a proper brain maturation. Recent animal work has shown that the structural brain development is clearly reflected in early EEG activity. Most important structures in this regard are the growing long range connections and the transient cortical structure, subplate. Sensory stimuli in a preterm baby will generate responses that are seen at a single trial level, and they have underpinnings in the subplate-cortex interaction. This brings neonatal EEG readily into a multimodal study, where EEG is not only recording cortical function, but it also tests subplate function via different sensory modalities. Finally, introduction of clinically suitable dense array EEG caps, as well as amplifiers capable of recording low frequencies, have disclosed multitude of brain activities that have as yet been overlooked.
In the practical part of this video, we show how a multimodal, dense array EEG study is performed in neonatal intensive care unit from a preterm baby in the incubator. The video demonstrates preparation of the baby and incubator, application of the EEG cap, and performance of the sensory stimulations.

This video explains the background theory of the neonatal EEG activity and the sensory responses, followed by a live demonstration of their recording in neonatal intensive care unit.

早産児脳波：マルチモーダル神経生理学的プロトコル

Since its introduction in early 1950s, electroencephalography (EEG) has been widely used in the neonatal intensive care units (NICU) for assessment and ...

Neonatal Pial Surface Electroporation

Over the past several years the pial surface has been identified as a germinal niche of importance during embryonic, perinatal and adult neuro- and gliogenesis, including after injury. However, methods for genetically interrogating these progenitor populations and tracking their lineages had been limited owing to a lack of specificity or time consuming production of viruses. Thus, progress in this region has been relatively slow with only a handful of investigations of this location. Electroporation has been used for over a decade to study neural stem cell properties in the embryo, and more recently in the postnatal brain. Here we describe an efficient, rapid, and simple technique for the genetic manipulation of pial surface progenitors based on an adapted electroporation approach. Pial surface electroporation allows for facile genetic labeling and manipulation of these progenitors, thus representing a time-saving and economical approach for studying these cells.

The pial surface is a unique progenitor zone in the CNS that is receiving increasing attention. Herein, we detail a method for rapid genetic manipulation of this progenitor zone using a modified electroporation method. This procedure can be used for cellular and molecular investigations of cell lineages and signaling pathways involved in cell differentiation and to elucidate the fate and properties of daughter cells.

新生児軟膜表面エレクトロ

Over the past several years the pial surface has been identified as a germinal niche of importance during embryonic, perinatal and adult neuro- and ...

Recording EEG in Freely Moving Neonatal Rats Using a Novel Method

EEG is a useful method to detect electrical activity in the brain. Moreover, it is a widely used diagnostic tool for various neurological conditions, such as epilepsy and neurodegenerative disorders. However, it is technically difficult to obtain EEG recordings in neonates as it requires specialized handling and great care. Here, we present a novel method to record EEG in neonatal rat pups (P8-P15). We designed a simple and reliable electrode using computer pin loci; it can be easily implanted into the skull of a rat pup to record high-quality EEG signals in the normal and epileptic brain. Pups were given an intraperitoneal (i.p.) injection of the neurotoxin kainic acid (KA) to induce epileptic seizures. The surgical implantation performed in this procedure is less expensive than other EEG procedures for neonates. This method allows one to record high-quality and stable EEG signals for more than 1 week. Furthermore, this procedure can also be applied to adult rats and mice to study epilepsy or other neurological disorders.

Here, we introduce a novel technique designed to record electroencephalography (EEG) in freely moving neonatal epileptic pups and describe its procedures, features, and applications. This method allows one to record EEG for more than 1 week.

新しい方法を用いた自由に動く新生児ラットの脳波記録

EEG is a useful method to detect electrical activity in the brain. Moreover, it is a widely used diagnostic tool for various neurological conditions, such ...

Application of an Amplitude-integrated EEG Monitor (Cerebral Function Monitor) to Neonates

Amplitude-integrated EEG (aEEG) is an easily accessible technique to monitor the electrocortical activity in preterm and term infants in neonatal intensive care units (NICUs). This method was first used to monitor newborns after asphyxia, providing information about future neurological outcomes. The aEEG is also helpful to select newborns who benefit from cooling. The aEEG monitoring of preterm infants is becoming more widespread, as various studies have shown that neurodevelopmental outcome is related to early aEEG tracings. Here, we demonstrate the application of the aEEG monitoring system and present typical patterns that depend upon gestational age and pathophysiological conditions. Furthermore, we mention pitfalls in the interpretation of the aEEG, as this method requires accurate fixation and localization of the electrodes. Additionally, the raw EEG can be used to detect neonatal seizures or to identify aEEG application problems. In conclusion, aEEG is a safe and generally well-tolerated method for the bedside monitoring of neonatal cerebral function; it can even provide information about long-term outcome.

Application of an Amplitude-integrated EEG Monitor Cerebral Function Monitor to Neonates

Here, we show how to apply amplitude-integrated electroencephalography to monitor cerebral function in neonates.

脳波振幅統合モニター (脳機能モニター) の新生児への応用

Amplitude-integrated EEG (aEEG) is an easily accessible technique to monitor the electrocortical activity in preterm and term infants in neonatal ...

医学

Objective Nociceptive Assessment in Ventilated ICU Patients: A Feasibility Study Using Pupillometry and the Nociceptive Flexion Reflex

The concept of objective nociceptive assessment and optimal pain management have gained increasing attention. Despite the known negative short- and long-term consequences of unresolved pain or excessive analgosedation, adequate nociceptive monitoring remains challenging in non-communicative, critically ill adults. In the intensive care unit (ICU), routine nociceptive evaluation is carried out by the attending nurse using the Behavior Pain Scale (BPS) in mechanically ventilated patients. This assessment is limited by medication use (e.g., neuromuscular blocking agents) and the inherent subjective character of nociceptive evaluation by third parties.
Here, we describe the use of two nociceptive reflex testing devices as tools for objective pain evaluation: the pupillary dilation reflex (PDR) and nociception flexion reflex (NFR). These measurement tools are non-invasive and well tolerated, providing clinicians and researchers with objective information regarding two different nociceptive processing pathways: (1)&#160;the pain-related autonomic reactivity&#160;and (2) the ascending component of the somatosensory system. The use of PDR and NFR measurements are currently limited to specialized pain clinics and research institutions because of impressions that these are technically demanding or time-consuming procedures, or even because of a lack of knowledge regarding their existence.
By focusing on the two abovementioned nociceptive reflex assessments, this study evaluated their feasibility as a physiological pain measurement method in daily practice. Pursuing novel technologies for evaluating the analgesia level in unconscious patients may further improve individual pharmacological treatment and patient related outcome measures. Therefore, future research must include large well-designed clinical trials in a real-life environment.

Pain assessment in anesthetized patients who cannot communicate with the outside world in any way remains challenging despite the development of innovative objective pain evaluation tools. In this project, the pupillary dilation reflex and the nociception flexion reflex are assessed in critically ill, mechanically ventilated adult patients.

換気の ICU 患者の客観的な受容評価: Pupillometry と侵害受容性屈曲反射を用いた可能性の検討

The concept of objective nociceptive assessment and optimal pain management have gained increasing attention. Despite the known negative short- and ...

How to Obtain Reliable Visual Event-related Potentials in Newborns

The present study discusses the characteristics of visual event-related potentials (VEPs) and outlines methodological steps for obtaining reliable measurements in newborns. Obtaining high-quality, reliable VEPs is crucial for the early detection of abnormal development of the central nervous system in at-risk newborns, and for implementing successful early interventions. Recommendations are based on a previous study which showed that when post-conceptional age, polysomnography-identified sleep stages, and light-emitting diodes (LEDs) googles as the luminous source are controlled, no more than 4 repetitions of VEP averages are required to obtain replicable recordings, variability decreases, and reliable VEPs can be obtained. By controlling for these sources of variability and using statistical analyses, we were able to clearly and reliably identify the amplitude and latency of three main components (NII, PII and NIII) present in 100% of newborns (n = 20) during active sleep. Recording VEPs during awake states, quiet sleep and transitional sleep is not recommended because VEP morphology may differ significantly from one average to the next, leading to the risk of misleading clinical prognoses. Moreover, it is easier to obtain VEPs during active sleep because this state can be clearly and reliably identified at this stage of development, sleep cycles are short enough to allow measurements to be taken in a reasonable time, and the method does not require new o expensive equipment.

Several important points for obtaining high-quality reliable visual evoked potentials (VEPs) in newborns while minimizing variability and the risk of misleading prognoses are presented.

新生児における信頼性の高い視覚イベント関連電位を得る方法

The present study discusses the characteristics of visual event-related potentials (VEPs) and outlines methodological steps for obtaining reliable ...

乳児輸送のためのポータブル振幅積分脳波計の使用

Amplitude-Integrated EEG in Infants at Risk of Hypoxic-Ischemic Encephalopathy: A Feasibility Study in Road and Air Transport in Western Australia

Infants at risk of HIE require early identification and initiation of therapeutic hypothermia (TH). Earlier treatment with TH is associated with better outcomes. aEEG is frequently used when making the decision whether to commence TH. As this is often limited to tertiary centers, TH may be delayed if the infant requires transport to a center that provides it. We aimed to provide a method for the application of amplitude-integrated electroencephalogram (aEEG) and to determine the feasibility of acquiring clinically meaningful information during transport. All infants &#8805;35 weeks, at risk of HIE at referral, were eligible for inclusion. Scalp electrodes were placed in the C3-C4; P3-P4 position on the infant&#39;s scalp and connected to the aEEG amplifier. The aEEG amplifier was, in turn, connected to a clinical tablet computer with EEG software to collect and analyze aEEG information. Recordings were reviewed by the chief principal investigator and two independent reviewers (blinded) for background trace and artifact. Predefined criteria for data quality were set to movement artifacts and software impedance notifications. Surveys were completed by healthcare staff and parents for acceptability and ease of use.

著者スポットライト:新生児輸送中の振幅積分EEGの使用の実現可能性の評価

Here, we present a feasibility study to assess a portable amplitude-integrated electroencephalogram (aEEG) recording system during the transport of infants with suspected hypoxic ischemic encephalopathy (HIE).

低酸素性虚血性脳症のリスクがある乳児における振幅積分脳波:西オーストラリア州の道路および航空輸送における実現可能性研究

Infants at risk of HIE require early identification and initiation of therapeutic hypothermia (TH). Earlier treatment with TH is associated with better ...

新生児脳波に結合されたフラット先端プローブを用いた有害誘発脳活動の電気生理学的測定

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幼児聴覚処理とイベント関連の脳の振動

電気生理学的測定とヒト幼児における痛覚の分析

早産児脳波：マルチモーダル神経生理学的プロトコル

新生児軟膜表面エレクトロ

新しい方法を用いた自由に動く新生児ラットの脳波記録

脳波振幅統合モニター (脳機能モニター) の新生児への応用

換気の ICU 患者の客観的な受容評価: Pupillometry と侵害受容性屈曲反射を用いた可能性の検討

新生児における信頼性の高い視覚イベント関連電位を得る方法

低酸素性虚血性脳症のリスクがある乳児における振幅積分脳波:西オーストラリア州の道路および航空輸送における実現可能性研究

低酸素性虚血性脳症のリスクがある乳児における振幅積分脳波:西オーストラリア州の道路および航空輸送における実現可能性研究